Malaria is one of the most important infectious diseases in the world and the Plasmodium falciparum parasite is the causative agent of most of the severe cases. The pathogenesis of the disease is complex but sequestration and hence microvascular obstruction is associated with virulence of the parasite. Rosetting, the adhesion of a parasitized red cell (pRBC) to two or more non-parasitized RBC i...

OBJECTIVES This study provides an in vitro analysis of dalbavancin activity against isolates causing skin and skin-structure infections (SSSIs) in children. METHODS A total of 770 Staphylococcus aureus, 167 β-haemolytic streptococci (BHS), 42 coagulase-negative staphylococci (CoNS), 25 Enterococcus faecalis and 13 viridans group streptococci (VGS) were collected from children (<18years old) i...

This paper confirms a conjecture of Amdeberhan and Moll that the power of 2 dividing the number of plane partitions in an n-cube is greater than the power of 2 dividing the number of totally symmetric plane partitions in the same cube when n is even, and less when n is odd.

Dennis O Mook-Kanamori ([email protected]) Sandra WK de Kort ([email protected]) Cornelia M van Duijn ([email protected]) Andre G Uitterlinden ([email protected]) Albert Hofman ([email protected]) Henriëtte A Moll ([email protected]) Eric AP Steegers ([email protected]) Anita CS Hokken-Koelega ([email protected]) Vincent WV Jaddoe (v.jaddoe@erasmusm...

Pexiganan, a 22-amino-acid synthetic cationic peptide, is currently in phase 3 clinical trials as a topical antimicrobial agent for the treatment of mild infections associated with diabetic foot ulcers. Bacterial isolates from the 2013 SENTRY Antimicrobial Surveillance Program designated as pathogens from diabetic foot infections (DFI) and Gram-negative and -positive pathogens from various infe...

Biapenem is a carbapenem being developed in combination with RPX7009, a new inhibitor of serine β-lactamases. Biapenem was tested alone and in combination with fixed concentrations of RPX7009 by agar dilution against 377 recent isolates of anaerobes. A separate panel of 27 isolates of Bacteroides spp. with decreased susceptibility or resistance to imipenem was also tested. Comparator drugs incl...

Increasing evidence demonstrates that interleukin (IL)-32 is a pro-inflammatory cytokine, inducing IL-1alpha, IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and chemokines via nuclear factor (NF)-kappaB, p38 mitogen-activated protein kinase (MAPK), and activating protein (AP)-1 activation. Here we report that IL-32 is expressed and is also functional in human vascular endothelial cells (EC)...