AbstractBackground Bariatric surgery is a standard treatment for severe obesity, but little known about patients' perceptions the long-term impact of such surgery. Objective The aim this study was to explore experiences living with bariatric procedure more than decade. Setting University hospital. Methods At 10-year follow-up after undergoing Roux-en...

ABSTRACT Background: Sacral-alar-iliac (SAI) screws are increasingly used for lumbo-pelvic fixation procedures. Insertion of SAI is technically challenging, and surgeons often rely on costly time-consuming navigation systems. We investigated the accuracy precision an augmented reality (AR)–based commercially available head-mounted device requiring minimal infrastructure. M...

Importance Gestational diabetes is associated with several poor health outcomes. Objective To update the 2012 review on screening for gestational to inform US Preventive Services Task Force. Data Sources MEDLINE, EMBASE, and CINAHL (2010 May 2020), ClinicalTrials.gov, reference lists; surveillance through June 2021. Study Selection English-language interventi...

AbstractObjectives Mental fatigue impairs endurance exercise. Brain training (BET) – engaging in cognitively fatiguing tasks during exercise - can develop resilience to mental and improve physical performance over alone. The mechanism for this effect is unknown. This experiment examines if BET enhances investigates potential underlying physiological mechanisms. Design...

Introduction: Coronavirus disease 2019 (COVID-19) disrupted and undermined primary care delivery. The goal of this study was to examine the financial impacts pandemic has had on clinicians practices. Methods: American Academy Family Physicians National Research Network Robert Graham Center distributed weekly surveys from March 27, 2020, through June 15, a network more than 196...

SummaryBackground Identifying patients at higher risk of healthcare-associated infections (HAIs) in intensive care units (ICUs) represents a major challenge for public health. Machine learning could improve patient stratification and lead to targeted infection prevention control interventions. Aim To evaluate the performance Simplified Acute Physiology Score (SAPS) II...

Introduction: The 2019 novel coronavirus (COVID-19) caused a global pandemic that forced medical providers to rapidly alter methods of health care delivery. One month into this pandemic, we surveyed and patients assess satisfaction or concerns with the change from in-person visits. Methods: We internal medicine (IM) family (FM) faculty residents ascertain telehealth Result...

Importance Ondansetron is frequently used to treat nausea and vomiting during pregnancy. Although some studies reported important safety signals, few have been sufficiently large assess rare pregnancy outcomes. Objective To study the association between ondansetron exposure risks of spontaneous abortion, stillbirth, major congenital malformations. Design, Setting, Particip...

Post-translational modifications (PTMs) of histone proteins play a fundamental role in regulation of DNA-templated processes. There is also growing evidence that proteolytic cleavage of histone N-terminal tails, known as histone clipping, influences nucleosome dynamics and functional properties. Using top-down and middle-down protein analysis by mass spectrometry, we report histone H2B and H3 N...

BACKGROUND Acetylation of lysine 56 of histone H3 plays an important role in the DNA damage response and it has been postulated to play an as yet undefined role in transcription, both in yeast and in higher eukaryotes. Because phosphorylated human histone H3 serine 57 peptides have been detected by mass spectrometry we examined whether H3-S57 phosphorylation interplays with H3-K56 acetylation i...