Plant viral vectors have become a promising tool for the rapid and cost-effective production of recombinant proteins in plants. Among numerous genera viruses that been used heterologous expression, potyviruses offer several advantages, such as polyprotein expression strategy or broad host range. In our work, pAD/pAD-agro based on plum pox virus (PPV) genome were different foreign polypeptides: ...

Abstract Background Hemagglutinin is a major surface protein in influenza A virus (IAV), and HA2 relative conserved among different IAVs. It will be meaningful to identify broad-spectrum epitopes based on the protein. Results Overlapping peptides of H5N1 IAV A/Mallard/Huadong/S/2005 were synthesized loaded modified silica gel film form microarray, antisera against subtypes IAVs used screen univ...

Treatment of respiratory viral infections remains a global health concern, mainly due to the inefficacy available drugs. Therefore, discovery novel antiviral compounds is needed; in this context, antimicrobial peptides (AMPs) like temporins hold great promise. Here, we discovered that harmless temporin G (TG) significantly inhibited early life-cycle phases influenza virus. The vitro hemagglutin...

A conserved epitope is an epitope retained by multiple strains of influenza as the key target of a broadly neutralizing antibody. Identification of conserved epitopes is of strong interest to help design broad-spectrum vaccines against influenza. Conservation score measures the evolutionary conservation of an amino acid position in a protein based on the phylogenetic relationships observed amon...