Radix Notoginseng (commonly known as notoginseng or sanqi) is an herb primarily indicated for bloodand circulation-related conditions. In traditional Chinese medicine, notoginseng is often used together with other herbs to halt both internal and external bleeding, although the effects are mostly attributed to notoginseng itself [1]. Experimental findings have provided support to other effects, ...

When end stage liver disease occurs, liver transplantation is the only effective treatment available. In the past, liver transplantation was frequently accompanied by considerable bleeding complications and massive transfusion requirements, while only in recent years advances in operative management and a better understanding of the pathophysiology of coagulation have determined a better outcom...

The PFA-100 provides a simple global measure of high shear-dependent platelet function, and as such is not diagnostic or specific to any disorder. Prolonged closure times must be interpreted in conjunction with a full blood count, von Willebrand factor (VWF) screen and other platelet tests. The PFA-100 may also give false negative results with relatively common platelet defects. If clinical sus...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

the support vector machine (svm) is a relatively new machine learning method which is increasingly being applied to engineering problems and have yielded encouraging results. because of complex behavior of elastoplastic of web panels of plate girders under patch loading, almost none of the proposed methods provides consistent and accurate predictions of patch load capacity. consequently, altern...

Several haemostatic abnormalities have been reported in thyroid hormone excess. However, the overall effect on coagulation and fibrinolysis is still unclear. We were presented the unique opportunity to further explore the effects of excessive levels of thyroid hormone in the case of a young woman who attempted suicide by auto-intoxication with levothyroxine. Levels of thyroid hormones and param...

Ankaferd Blood Stopper (ABS), a standardized mixture of five plants, has been used historically as a haemostatic agent but its mechanism of action remains unknown. This study investigated the in vitro effects of ABS on haemostatic parameters. When added to plasma or serum, ABS induced the very rapid formation of a protein network and erythrocyte aggregation. The levels of coagulation factors II...

The endothelium is a widely distributed organ system that plays an important role in health and disease. The endothelium is remarkably heterogeneous in structure and function. One vital function of the endothelium is to maintain blood in its fluid state, and to provide controlled haemostasis at sites of vascular injury. In keeping with the theme of endothelial cell heterogeneity, endothelial ce...

second only to HIV/AIDS as a cause of death. Each year, worldwide, over three million people die as a result of trauma, many after reaching hospital.1 Among trauma patients who do survive to reach hospital, exsanguination is a common cause of death, accounting for nearly half of in-hospital trauma deaths.2 Central nervous system injury and multi-organ failure account for most of the remainder, ...

-This paper is aimed at investigating how metastatic tumour growth influenced the haemostatic system of the host. Blood platelet count, blood fibrinogen level, the activated partial thromboplastin time (APTT) and the prothrombin time (PT) were determined at various intervals during growth and metastasis of a murine fibrosarcoma (mFS6) or one of its sublines with different metastatic capacity. P...