Polyaza-heterocycles show a plethora of biological properties and represent significant percentage clinically used drugs. However, the imizado[1,2-a]pyrimidine ring system needs more attention in terms pharmaceutical applications. Herein, we report sequence involving an aldolic condensation/bromination/Hantzsch reaction to construct series 2-alkenylimidazo[1,2-a]pyrimidines for exploring their ...