Using an HPLC procedure, we evaluated > 10 minor hemoglobins (Hbs) in healthy adults, individuals on long-term aspirin therapy, diabetic subjects, and uremic patients. Hb A1c and Hb A1d3 were the most abundant and important minor Hb components, respectively, accounting for 4.10% +/- 0.50% and 3.46% +/- 0.43% of total Hb in 361 healthy subjects. Acetylated Hb A was a potential interferent in the...

OBJECTIVE Hemoglobin α (Hb α) and endothelial nitric oxide synthase (eNOS) form a macromolecular complex at myoendothelial junctions; the functional role of this interaction remains undefined. To test if coupling of eNOS and Hb α regulates nitric oxide signaling, vascular reactivity, and blood pressure using a mimetic peptide of Hb α to disrupt this interaction. APPROACH AND RESULTS In silico...

During embryonic development, the positional information provided by concentration gradients of maternal factors directs pattern formation by providing spatially dependent cues for gene expression. In the fruit fly, Drosophila melanogaster, a classic example of this is the sharp on-off activation of the hunchback (hb) gene at midembryo, in response to local concentrations of the smooth anterior...

HbA2' (also called Hb B2) is the most common delta-globin chain defect and is reported to occur in 1-2% of the African American population. The major clinical significance of HbA2' is that the failure to detect it might lead to an underestimation of the total HbA2, leading to failure to diagnose β-thalassemia minor. In order to diagnose β-thalassemia minor, both HbA2 and HbA2' levels must be co...

An algorithm for the identification of a multi-input single-output (MISO) Box-Jenkins model is developed. The method consists of several simple steps: first a high order ARX model is estimated; then the process model is calculated using the so-called Steiglitz-McBride iteration on the filtered inputoutput data; and finally the disturbance model is calculated by estimating an ARMA model of the o...

This paper describes an optimal instrumental variable method for identifying discrete-time transfer function models of the Box-Jenkins transfer function form in the closed-loop situation. This method is based on the Refined Instrumental Variable (RIV) algorithm which, because of an appropriate choice of particular design variables, achieves minimum variance estimation of the model parameters. T...

Dalbergia melanoxylon Gill. & Perr. known as African Blackwood or Mpingo in Swahili is a flowering plant in the family Fabaceae known to be an economically important tree with high-quality wood and being one of the most expensive timbers in the world (Jenkins et al. 2002, Ball, 2004). D. melanoxylon presently exploited for international trade is the most precious heartwood in the world (Ball, 2...

Malabari Goat populations of Tanur, Thalassery and Badagara were studied for haemoglobin polymorphism. Two variants were observed for haemoglobin, Hb A and Hb B with a frequency of 0.987 and 0.012, respectively, suggestive of three phenotypes, viz. Hb AA, Hb AB and Hb BB, and indicating the predominance of Hb A in the pooled population. Hb B variant was observed only in the Thalassery populatio...