Abstract Background Hepatocellular carcinoma (HCC), derived from hepatocytes, is the main histological subtype of primary liver cancer and poses a serious threat to human health due high incidence poor prognosis . This study aimed establish multigene prognostic model predict patients with HCC. Results Gene expression datasets (GSE121248, GSE40873, GSE62232) were used identify differentially exp...

Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related death in China. Deregulation of microRNA (miRNA) contributes to HCC development by influencing cell growth, apoptosis, migration or invasion. It has been proved that miR-940 plays important roles in various cancers. Here we investigated the role of miR-940 in HCC. We found that miR-940 was remarkably decreased in HCC t...

Recently, <span>computer-aided diagnostic systems for various diseases have received great attention. One of the latest technologies used is deep learning architectures analyzing and classifying medical images. In this paper, a new system that uses to classify three focal in liver besides normal proposed. A pre-trained convolutional neural network utilized. Two types networks are used, Re...

Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality and increasing in incidence worldwide. Early detection HCC important since potentially curative therapies exist initial stages HCC; no for late-stage HCC. However, remains challenging due to lack symptoms during early stage disease. Other methods screening detecting HCC, including blood serum tests conventional imagin...

Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Effective treatment of HCC patients is hampered by the lack of sensitive and specific diagnostic markers of HCC. Alpha-fetoprotein (AFP), the currently used HCC marker, misses 30%-50% of HCC patients, who therefore remain undiagnosed and untreated. In order to identify novel diagnostic markers that can be used...

Hepatocellular carcinoma (HCC) is one of the most common malignancies that results from genes regulation via different pathways. NME/NM23 nucleoside diphosphate kinase 1 (NME1) is generally regarded as a metastasis suppressor, but its function in HCC is largely unknown. In our study, we explored the role of NME1 in HCC. By analyzing the gene expression omnibus (GEO) database, we discovered that...

    Abstract   Background: Hepatitis B virus infection is an important cause of liver morbidity and   mortality worldwide. HDV changes the natural course of HBV. The prevalence of HDV infection wasn’t determined in the various groups of HBV infection (carriers, acute hepatitis, chronic hepatitis, cirrhosis and HCC) in Iran. We aimed to research the prevalence of hepatitis D virus infection in v...

The TERT gene encodes its catalytic subunit that is essential for telomere length at the chromosome ends. expression of highly associated with risk human cancers. Recurrent mutations in promoter are identified as a mechanism to activate telomerase cancer. This study aims determine rate hepatocellular carcinoma (HCC) tissue samples and association between some factors HCC. was conducted on 84 pa...

Non-alcoholic fatty liver disease (NAFLD) is rapidly emerging as a leading etiology of chronic (CLD) in Asia. The increasing incidence NAFLD projected to drive surge NAFLD-related hepatocellular carcinoma (HCC). A notable characteristic NAFLD-HCC its capacity for development individuals without cirrhosis more than third patients. Most practice guidelines recommend biannual ultrasound screening ...

: In this short commentary, we discuss the most important risk factors for liver cancer. One of the most striking risks is infection with hepatitis B and C viruses, leading to chronic hepatitis, which may later develop into hepatocellular carcinoma (HCC). The use of alcohol may lead to cirrhosis, which is scarring the liver, is associated with 30 a more increase in HCC and 10-20 times more incr...