The globus pallidus (GP) is a critical component of the basal ganglia circuitry controlling motor behavior. Dysregulation of GP activity has been implicated in a number of psychomotor disorders, including Parkinson's disease (PD), in which a cardinal feature of the pathophysiology is an alteration in the pattern and synchrony of discharge in GP neurons. Yet the determinants of this activity in ...

We present significantly improved one-to-one routing algorithms in the datacenter networks HCN and BCN in that our routing algorithms result in much shorter paths when compared with existing routing algorithms. We also present a much tighter analysis of HCN and BCN by observing that there is a very close relationship between the datacenter networks HCN and the interconnection networks known as ...

This poster presents single-dish and aperture-synthesis observations of the J=1–0 (λ ≈ 3 mm) transitions of HCO, HCN, and N2H + towards the Serpens star-forming region. Jets driven by young stars affect the structure and the chemistry of their surrounding cloud, and this work aims to assess the extent to which the emission of these three molecular lines is dominated by such processes. In Serpen...

The physiological dormancy of sunflower (Helianthus annuus) embryos can be overcome during dry storage (after-ripening) or by applying exogenous ethylene or hydrogen cyanide (HCN) during imbibition. The aim of this work was to provide a comprehensive model, based on oxidative signaling by reactive oxygen species (ROS), for explaining the cellular mode of action of HCN in dormancy alleviation. B...

Layer 1 (L1) interneurons (INs) play a key role in modulating the integration of inputs to pyramidal neurons (PNs) and controlling cortical network activity. Hyperpolarization-activated, cyclic nucleotide-gated, non-specific cation (HCN) channels are known to alter the intrinsic and synaptic excitability of principal components (PCs) as well as select populations of GABAergic INs. However, the ...

The HCN 1–0 hyperfine lines have been observed toward 24 young stellar objects (YSOs) of class 0 and I. The hyperfine lines are well separated in most cases and show such rich structures as asymmetric double peaks and strong wings. We examined how their line shapes and velocity shifts vary along with their relative optical depths and compared them with those of CS 2–1, H 2 CO 2 12 –1 11 , and H...

The three adiabatic potential surfaces of the Br(2P)-HCN complex that correlate to the 2P ground state of the Br atom were calculated ab initio. With the aid of a geometry-dependent diabatic mixing angle, also calculated ab initio, these adiabatic potential surfaces were transformed into a set of four diabatic potential surfaces required to define the full 3 x 3 matrix of diabatic potentials. E...

Hyperpolarization-activated cyclic nucleotide-gated (HCN 1-4) channels are the molecular determinants of If/Ih, a mixed cation inward current that controls firing automaticity in pacemaker cells. HCN primarily activated by membrane hyperpolarization, and further regulated cAMP binding to cytosolic nucleotide domain (CNBD). Biochemical measurements ligand purified eukaryotic proteins challenging...

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal excitability, pacemaking, dendritic integration, and homeostatic plasticity and are culprits in aberrant neuronal activity in certain epilepsies. In this issue of Neuron two manuscripts (Santoro et al. and Zolles et al.) report that HCN channel gating and expression are controlled by Trip8b (Pex5R) but with a b...