Chromosomal instability could be one of primary causes for malignant cell transformation. The objective of the present study was to evaluate the spontaneous genetic damages in circulated lymphocytes of newly diagnosed cancer patients by using cytokinesis-block micronucleus (CBMN) assay, with respect to the factors that might affect micronucleus frequency (i.e. age, gender, smoking habits and ca...

Purpose: It is essential to maintain dynamic stability during walking to perform daily tasks independently. The present study aimed at comparing the spatiotemporal parameters and the values of the vertical ground reaction force (vGRF) as well as determining the time to reach them in ankle-sprain coper and healthy athletes during the stance phase of gait. Methods: A total of 28 female universit...

Introduction: The altered serum profiles of several trace elements have been reported in Schizophrenia (SCZ). This study was designed to elucidate whether the serum levels of Copper (Cu) and Magnesium (Mg), the two essential trace elements which contribute to neurotransmitter transmission, are altered in patients with SCZ. We also investigated whether there is an interrelation between cognitive...

Early in development, GABA, an inhibitory neurotransmitter in adults, is excitatory. NKCC1 (SLC12A2) encodes one of two cation chloride cotransporters mediating the conversion of GABA from excitatory to inhibitory. Using 3' and 5' RACE and PCR, we verified previously characterized alternative transcripts of NKCC1a (1-27) and NKCC1b (1-27(Δ21)), identified new NKCC1 transcripts, and explored the...

BACKGROUND In spite of many similarities in the psychopathology of anorexia nervosa (AN) and bulimia nervosa (BN), the 2 groups seem to differ in terms of body image disturbances. Therefore, the aim of the present study was to compare neuronal correlates of viewing photographs of one's own body and another woman's body in patients with these forms of eating disorders as well as controls. METH...

OBJECTIVE There is evidence of an important role of immune system changes in the triggering and maintenance of idiopathic nephrotic syndrome (INS). The aim of this study was to investigate the expression of cytokines in lymphocyte populations of patients with INS in comparison to healthy individuals, according to proteinuria. METHODS This cross-sectional study included 44 patients with INS an...

OBJECTIVE Treatment with glucocorticoids and mineralocorticoids has changed congenital adrenal hyperplasia (CAH) from a fatal to a chronic lifelong disease. Long-term treatment, in particular the chronic (over-)treatment with glucocorticoids, may have an adverse effect on the cardiovascular risk profile in adult CAH patients. The objective of this study was to evaluate the cardiovascular risk p...

Background: Fibrinogen variants as a result of alternative mRNA splicing or protein degradation can affect fibrin(ogen) functions. The levels these might be altered during COVID-19, potentially affecting disease severity the thrombosis risk. Aim: To investigate fibrinogen in plasma patients with COVID-19. Methods: In this case-control study, we measured functional using Clauss assay. ELISAs wer...

background: allergic rhinitis (ar) is an allergic disorder of the nasal tissue that underlies diseases such as sinusitis, otits and asthma. different predisposing factors including immunological and non-immunological factors contribute to the disease pathogenesis. objective: to investigate association of haptoglobin (hp) phenotypes (hp1-1, 2-1 and 2-2) with serum immunoglobulins a and e levels ...