To evaluate the direct electrophysiologic effects of i.v. disopyramide phosphate and to differentiate these effects from its autonomically mediated actions, we administered the drug (2 mg/kg over 5 minutes) during electrophysiologic study to eight cardiac transplant recipients who had documented functional cardiac denervation. After disopyramide, the cycle length of the denervated donor right a...

Abstract A 57-year-old female presented to emergency with features of right heart failure. On evaluation, she was found have a large mass occupying atrium (RA) completely and protruding into ventricle through tricuspid valve. Intraoperatively, seen arising from RA free wall stony hard consistency. Histopathology revealed it be myxoma. We present this case for the rare presentation myxoma masque...

Hyperthyroidism has been associated with atrial fibrillation (AF), however, hyperthyroidism induced ion channel changes which may predispose to AF have not been fully elucidated. To understand the electrophysiological changes occurring in left and right atrium with hyperthyroidism, the patch-clamp technique was utilized to compare action potential duration (APD) and whole cell currents in myocy...

cor triatriatum   sinistrum is a rare congenital cardiac malformation, accounting for about 0.1-0.4% of all congenital heart diseases and characterized by the presence of a fibromuscular membrane that subdivides the left atrium into two chambers in the classical form. while classic cor triatriatum in most patients can be observed during the neonatal period or early infancy, it is very rare in a...

During the development of mammalian heart, left and right atria play an important role in cardiovascular circulation. The embryonic atrium is mainly formed by differentiation progenitor cells proliferation cardiomyocytes, while postnatal primarily shaped increase volume cardiomyocytes. Cell atrial basis for its functions such as “blood reservoir” “supplementary pump”. Deep understanding cellula...

To cite: Sethi T, Singh AP, Singla V, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2012008320 DESCRIPTION A 50-year-old woman presented with complaints of progressive breathlessness and easy fatiguability over the past 2 years. Jugular venous pressure was raised with absence of a wave. Cardiac auscultation revealed two distinct mid-diastolic murmurs at t...

Similar expression patterns of mRNA profiles for Endothelin 1 (ET-1) and Thrombospondin 1 (TSP1) from GeneAtlas U133A, gcrma, suggest that these two mediators are dominantly synthesized in the myocard and lungs. This paper proposes that intertraffic of these two mediators between myocard and lungs via pulmonary and coronary vessels optimizes cardiopulmonary functions and maintains their tissue ...

RATIONALE The second heart field (SHF) contains progenitors of all heart chambers, excluding the left ventricle. The SHF is patterned, and the anterior region is known to be destined to form the outflow tract and right ventricle. OBJECTIVE The aim of this study was to map the fate of the posterior SHF (pSHF). METHODS AND RESULTS We examined the contribution of pSHF cells, labeled by lipophi...

We report a case who presented to our emergency department with symptoms of congestive heart failure and acute pulmonary edema. The transthoracic echocardiography demonstrated a large tumor that occupied two-thirds of the left atrium and impeded the mitral valve flow. The patient underwent cardiac surgery with removal of the LA tumor that was intraoperatively found extending through the right i...