Objective(s): Drug-induced atrial fibrillation (AF) is considered an adverse effect of chemotherapeutic drugs. AF is a crucial risk factor for stroke, heart failure, myocardial infarction, and mortality. Pulmonary veins (PVs) are considered triggers inducing AF, and the sinoatrial node (SAN) may modulate PV activity and participate in AF genesis. AF was associated with...

Objective To assess the incidence and predictors of heart rhythm and conduction disturbances in hypertensive obese patients with and without obstructive sleep apnea (OSA). Methods This is an open, cohort, prospective study. Out of 493 screened patients, we selected 279 hypertensive, obese individuals without severe concomitant diseases: 75 patients without sleep-disordered breathing (non-SDB gr...

THE electrocardiogram in patients with tetralogy of Fallot usually shows right axis deviation and right ventricular hypertrophy. After creation of a systemic-pulmonary artery anastomosis, the work of the left ventricle increases, usually accompanied by a corresponding increase in the pattern of left ventricular loading." 2 Following openheart surgery, with closure of the ventricular septal defe...

Disturbances of conduction in the heart may be purely functional, when for example demands are made on the conduction path very early in diastole as seen in blocked and aberrantly conducted auricular extrasystoles (Scherf and Boyd, 1940), or when too many stimuli are presented for conduction within a short time as with the incomplete A-V block that always exists in auricular fibrillation. Condu...

THE electrocardiogram in patients with tetralogy of Fallot usually shows right axis deviation and right ventricular hypertrophy. After creation of a systemic-pulmonary artery anastomosis, the work of the left ventricle increases, usually accompanied by a corresponding increase in the pattern of left ventricular loading." 2 Following openheart surgery, with closure of the ventricular septal defe...

BACKGROUND The early phase of action potential (AP) repolarization is critical to impulse conduction in the heart because it provides current for charging electrically coupled cells. In the present study we tested the impact of heart failure-associated electrical remodeling on AP propagation. METHODS AND RESULTS Subepicardial, midmyocardial, and subendocardial myocytes were enzymatically diss...

Efficient blood flow depends on two developmental processes that occur within the atrioventricular junction (AVJ) of the heart: conduction delay, which entrains sequential chamber contraction; and valve formation, which prevents retrograde fluid movement. Defects in either result in severe congenital heart disease; however, little is known about the interplay between these two crucial developme...

INTRODUCTION Catheter ablation of arrhythmias can be challenging in patients with congenital heart disease (1). Besides the complexity of the arrhythmias seen in these patients, variations in the anatomy of the normal conduction system also contribute to that challenge. Arrhythmias following surgical repair of congenital heart defects are particularly more difficult to deal with (2). In this ar...

Intravenous magnesium has been used to prevent and treat many different types of cardiac arrhythmia. It has diverse electrophysiological actions on the conduction system of the heart; including prolonging sinus node recovery time, and reducing automaticity, atrioventricular nodal conduction, antegrade and retrograde conduction over an accessory pathway, and His-ventricular conduction. Intraveno...