background : the signal-averaged electrocardiography is a noninvasive method to evaluate the presence of the potentials generated by tissues activated later than their usual timing in the cardiac cycle. the purpose of this study was to demonstrate the correlation between the filtered qrs duration obtained via the signal-averaged electrocardiography and left ventricular dimensions and volumes an...

The prevalence and characteristics of right heart endocarditis in Africa are not well known. The aim of this study was to describe the epidemiological, clinical and laboratory profiles of patients with right-heart infective endocarditis. This was a 10-year retrospective study conducted in 2 cardiology departments in Dakar, Senegal. All patients who met the diagnosis of right heart infective end...

INTRODUCTION Patients with heart failure have a significant symptom burden and other palliative care needs often over a longer period than patients with cancer. It is acknowledged that this need may be unmet but by how much has not been quantified in primary care data at the population level. METHODS This was the first use of Clinical Practice Research Datalink, the world's largest primary ca...

The effects of hypercapnia, together with low and high levels of extracellular Ca(2+), on heart activity and intracellular pH were examined in isolated perfused hearts from the land snail Helix lucorum. In addition, the intracellular level of Ca(2+) was determined in slices of ventricles superfused with both normal and hypercapnic salines, containing low and high concentrations of Ca(2+), to in...

OBJECTIVE To determine the association between alcohol drinking patterns and risk of coronary heart disease in women and men. DESIGN Population based cohort study. SETTING Denmark, 1993-2002. PARTICIPANTS 28 448 women and 25 052 men aged 50-65 years, who were free of cardiovascular disease at entry to the study. MAIN OUTCOME MEASURES Incidence of coronary heart disease occurring during ...

Congenital heart defects are the clinical manifestation of anomalies in embryonic cardiac development. Such defects occur in distinct regions or chambers of the heart. A molecular framework in which to consider cardiac development and congenital heart disease in a segmental fashion has begun to emerge. dHAND and eHAND are two related basic helix-loop-helix transcription factors that are express...

OBJECTIVE To examine the associations between positive and negative affect and subsequent coronary heart disease events independently of established risk factors. DESIGN Prospective cohort study with follow-up over 12 years. SETTING 20 civil service departments originally located in London. PARTICIPANTS 10,308 civil servants aged 35-55 years at entry into Whitehall II study in 1985. MAI...

Kotecha, Neela, and Michael A. Hill. Myogenic contraction in rat skeletal muscle arterioles: smooth muscle membrane potential and Ca signaling. Am J Physiol Heart Circ Physiol 289: H1326–H1334, 2005. First published April 29, 2005; doi:10.1152/ajpheart.00323.2005.—The present studies examined relationships between intraluminal pressure, membrane potential (Em), and myogenic tone in skeletal mus...

Copello JA, Zima AV, Diaz-Sylvester PL, Fill M, Blatter LA. Ca entry-independent effects of L-type Ca channel modulators on Ca sparks in ventricular myocytes. Am J Physiol Cell Physiol 292: C2129–C2140, 2007. First published February 21, 2007; doi:10.1152/ajpcell.00437.2006.—During the cardiac action potential, Ca entry through dyhidropyridine receptor L-type Ca channels (DHPRs) activates ryano...