Incubation of phenobarbital-induced rat liver microsomes with 2,2',5,5'-tetrachlorobiphenyl (TCB) yielded about 30% of the substrate as 3-hydroxy-TCB, 3,4-dihydroxy-TCB, 3,3'-dihydroxy-TCB (tentative identification), and 3,4-dihydro-3,4-dihydroxy-TCB in relative amounts of about 1:1:0.05:0.05. Under identical conditions, 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide (TCBO) yielded about 45% of the su...

Male Fischer rats which had been implanted with a heterotopic bladder were randomly divided into five groups and their heterotopic bladders were instilled once a week for 20 weeks with 0.5 ml phosphate-buffered saline:dimethyl sulfoxide solution (4:1) or this solution containing 1 mumol benzidine (BZ), N'-hydroxy-N-acetylbenzidine, the N'-glucuronide of N'-hydroxy-N-acetylbenzidine, or the N-gl...

Ser (= /3-hydroxy Ala) belongs to the proteinogenic amino acids while other /3-hydroxy amino acids prevail in bacterial peptidic metabolites, often acting as Fe3+ chelating ligands. Thus, ß-hydroxy Asp is frequently encountered in the Pseudomonas siderophores (pyoverdins) [1], /3-Hydroxy Leu and 3-hydroxy-3-methyl Pro were recently found in a depsipeptide from Streptomyces sp. [2], L-Erythro-ß-...

N-Hydroxy-2-acetylaminofluorene (N-hydroxy-AAF), in conjugated form, was identified as a urinary metabolite of 2-acetylaminofluorene (AM') in male mongrel dogs. This metabolite was isolated and characterized in crystalline form. 7-Hydnoxy AM', in conjugated form, and AM? were also found in the urine of dogs fed AAF; no 1-, 3-, or 5-hydroxy-AAF was detected. The ingestion of N-hydroxy-AAF led to...

Here we evaluated the levels of lipid oxidation products, fatty acids, ascorbic acid and colour Porphyra Ulva after oven-drying at 40 °C, during subsequent storage for ?370 days under light, semi-light dark conditions. Part seaweed was pre-soaked in freshwater or pre-coated with a whey protein mixture. Controls consisted freeze-dried seaweeds. Throughout there moderate development oxidation-der...

Urinary N-hydroxy metabolites of the bladder carcinogens, 2-aminofluorene and 4-aminobiphenyl, were examined for the induction of unscheduled DNA synthesis (UDS) in urothelial cells of several susceptible species. N-Hydroxy-2-aminofluorene, N-hydroxy-2-acetylaminofluorene (N-OH-AAF), N-hydroxy-4-aminobiphenyl, N-hydroxy-4-acetylaminobiphenyl, and the N-glucuronides of these two hydroxylamines i...

in this work needle like hydroxy apatite were synthesized in a reverse microemulsion droplets of water in cyclohexane, separated by a cationic surfactant and co-surfactant, in the presence of na-polyacrylate (paa) as an anionic polyelectrolyte. characterization of the as formed hap nanoparticles at the room temperature were carried out by x-ray diffraction (xrd) and fourier transform infrared s...

in this study, the adsorption of 4-hydroxy phenyl-azobenzene on the surface of (4, 0) zigzag open-end boron nitride nanotube (bnnt) has been investigated by quantum calculations. in order to find the preferred adsorption site, different positions and orientations were considered. the impacts of donor-acceptor electron delocalization on the structural and electronic properties and reactivity of ...

Lanthanide ions, Ln(III), are of interest in the treatment of bone density disorders because they are found to accumulate preferentially in bone (in vivo), have a stimulatory effect on bone formation, and exhibit an inhibitory effect on bone degradation (in vitro), altering the homeostasis of the bone cycle. In an effort to develop an orally active lanthanide drug, a series of 3-hydroxy-4-pyrid...