The effects of 9 calcium antagonists on ABCG2/BCRP-mediated resistance and transport were examined in HeLa and SN-38-resistant HeLa (HeLa/SN100) cells, overexpressing ABCG2/BCRP. Sensitivity to mitoxantrone, an ABCG2/BCRP substrate, in HeLa/SN100 cells was significantly reversed by the coexistence of the calcium antagonists, except for diltiazem a...

Background/Aim. The use of cisplatin as a chemotherapeutic opened the door to new metal-based drug research. New complexes containing metals such platinum, palladium, ruthenium and gold have recently been analyzed potential antitumor agents. aim study was investigate cytotoxicity Au(III) with pincer-type ligands against cervical carcinoma cells (HeLa), breast cancer (MDA-MB-231 4T1) colon (HCT1...

Two new compounds, isostreptazolin (1) and sannaphenol (2), were isolated from the culture broth of Streptomyces sannanensis and their structures elucidated on the basis of 1D and 2D NMR as well as MS, IR and UV spectroscopic data analysis. The cytotoxic activity of 1 and 2 were evaluated. Both compounds were inactive against H460 and HeLa cell lines at 100 mM.

Six protoflavonoids, including two new compounds, were isolated during a large scale screening of fern extracts for original interaction with mitosis. The new compounds isolated from PHEGOPTERIS decursive-pinnata and EQUISETUM fluviatile were 2',3'-dihydroprotogenkwanone (1) and 2',3'-dihydro-2'-hydroxyprotoapigenone (2). Known compounds were: protoapigenone, protogenkwanone, protoapigenin, and...

Inactive nuclei of chick erythrocyte resume RNA synthesis and increase in volume and dry mass in heterokaryons made by virus-induced fusion of human tumor cells (HeLa) with chick erythrocytes. Nuclear growth is due primarily to migration of human macromolecules into the chick nucleus. Human nucleoplasmic antigens were detected in the nucleoplasm and human nucleolar antigens were detected in the...

Regarding the high prevalence of cancer, research on medicinal plants have been increased due to their availability, cost, and the presence of anticancer compounds. Rorippa nasturtium aquaticum, also called watercress, is a plant from the Brassicaceae family which has large amounts of antioxidants. The present study aimed to examine the antioxidant properties and the phenolic, flavonoid, and an...

Purpose: To explore the functions and regulatory mechanisms of synaptopodin-2 (SYNPO2) in cervical cancer progression.
 Methods: Normal cell lines (Ect1/E6E7) (HeLa, SiHa, C-33A, CaSki) were cultured. The pcDNA3.1 vector overexpressing SYNPO2, a negative control (vector), blank (control) transfected into HeLa SiHa cells. Protein expression from normal was examined by western blot. Cell via...

The interaction between tumor cells and surrounding normal cells is very important in the prognosis of tumors. The object of this study was to determine the effect of recipient bed of tumor xenograft on tumor metastasis using a novel parotid gland tumor model. HeLa cells were xenografted into the parotid gland or subcutaneous tissues of athymic mice. Eight weeks after the transplantation, all m...

BACKGROUND Cancer stem cells (CSCs) are proposed to be responsible for high recurrence rate in cervical carcinoma. Reagents that can suppress the proliferation and differentiation of CSCs would provide new opportunities to fight against tumor recurrence. Doxycycline has been reported as a potential anti-cancer compound. However, few studies investigated its inhibitory effect against cervical ca...