نتایج جستجو برای: hemagglutinin gene

تعداد نتایج: 1147419  

2014
Nicolas Jacquet Catherine Navarre Daniel Desmecht Marc Boutry

The expression of recombinant hemagglutinin in plants is a promising alternative to the current egg-based production system for the influenza vaccines. Protein-stabilizing fusion partners have been developed to overcome the low production yields and the high downstream process costs associated with the plant expression system. In this context, we tested the fusion of hydrophobin I to the hemagg...

2014
Hoang Trong Phan Bettina Hause Gerd Hause Elsa Arcalis Eva Stoger Daniel Maresch Friedrich Altmann Jussi Joensuu Udo Conrad

Fusion protein strategies are useful tools to enhance expression and to support the development of purification technologies. The capacity of fusion protein strategies to enhance expression was explored in tobacco leaves and seeds. C-terminal fusion of elastin-like polypeptides (ELP) to influenza hemagglutinin under the control of either the constitutive CaMV 35S or the seed-specific USP promot...

2017
Henning Jacobsen Madhusudan Rajendran Angela Choi Haakon Sjursen Karl A Brokstad Rebecca J Cox Peter Palese Florian Krammer Raffael Nachbagauer

The immunogenicity of current influenza virus vaccines is assessed by measuring an increase of influenza virus-specific antibodies in a hemagglutination inhibition assay. This method exclusively measures antibodies against the hemagglutinin head domain. While this domain is immunodominant, it has been shown that hemagglutination inhibition titers do not always accurately predict protection from...

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