BACKGROUND We aimed to evaluate the safety and efficacy of single-agent sunitinib in nasopharyngeal carcinoma (NPC). METHODS Eligible patients had progressive disease after prior platinum-based chemotherapy. Sunitinib was given as continuous once-daily dosing of 37.5 mg in 4-week cycles until progression. RESULTS Thirteen patients were enrolled. Recruitment was stopped after two patients di...

Objective: The objective of the study is to calculate the frequency of portal vein thrombosis in pediatric patients presenting with hematemesis and to estimate the frequency of acute and chronic portal vein thrombosis in these cases. Patients and Methods: Pediatric patients of 1 – 15 years of age of either sex, presenting to emergency or gastroenterology department with complaint of hematemesis...

Peptic ulcer is a Common diseuse with potentially serious complications. Perforation of the one such complication that can be fatal if left untreated. We present rare case kissing peptic ulcers in 42-year-old patient who presented hematemesis and melena was admitted to intensive care unit hemorrhagic shock post trauma. Despite failed endoscopic hemostasis measures, successfully treated surgical...

INTRODUCTION The pattern of bleeding tendencies in dengue and its corellation with platelet count and other factors requires clarification. METHODOLOGY A retrospective study on bleeding tendencies in adults with dengue and platelet counts of less than 100,000 per mm(3) was conducted. Factors associated with bleeding were analyzed. The study cohort were grouped as dengue with severe thrombocyt...

Hydrogen peroxide is a common over-the-counter solution that has developed a growing body of literature regarding toxic ingestion. Intentional ingestion of high concentration hydrogen peroxide for health purposes has gained popularity in certain patient populations; purported benefits are due to the increased oxygen released into the blood stream. We present for evaluation one such case with as...

OBJECTIVE To evaluate the clinical presentation, possible etiological factors, management and outcome of patients in our hospital with extrahepatic portal vein obstruction (EHPVO). MATERIALS AND METHODS This study included patients with EHPVO followed up in our department during last 10 years. Patients of cirrhosis with EHPVO were excluded. Patients' clinical presentation, etiology of EHPVO, ...

A man in his 70s presented to the emergency unit for hematemesis. His recent blood test showed normal liver and renal function, and serum anti-Helicobacter pylori (H. pylori) IgG antibody was negative. He took neither steroids nor nonsteroidal anti-infl ammatory drugs (NSAIDs). Emergency endoscopy revealed a bleeding gastric ulcer in the greater curvature of the gastric body (Fig. 1A). Endoscop...

RATIONALE Ectopic variceal bleeding is a rare (2-5%) but fatal gastrointestinal bleed in patients with portal hypertension. Patients with ectopic variceal bleeding manifest melena, hematochezia, or hematemesis, which require urgent managements. Definitive therapeutic modalities of ectopic varices are not yet standardized because of low incidence. Various therapeutic modalities have been applied...

Twenty cases of ALP poisoning aged between 7-12 years who were admitted in the Pediatric Emergency Services between July 1995 to July 1996 were evaluated. The diagnosis was made on the basis of the history of ingestion and positive silver nitrate tests on gastric lavage fluid. All routine investigations including, serum electrolytes, liver function tests, renal function tests, acid blood gas an...