Inhibitory molecules such as PD-1, CTLA-4, LAG-3, or TIM-3 play a role to keep a balance in immune function. However, many cancers exploit such molecules to escape immune surveillance. Accumulating data support that their functions are dysregulated in lymphoid neoplasms, including plasma cell myeloma, myelodysplastic syndrome, and acute myeloid leukemia. In lymphoid neoplasms, aberrations in 9p...

Overwhelming post-splenectomy infection (OPSI) is a rare medical emergency, mainly caused by encapsulated bacteria, shortly progressing from a mild flu-like syndrome to a fulminant, potentially fatal, sepsis. The risk of OPSI is higher in children and in patients with underlying benign or malignant hematological disorders. We retrospectively assessed OPSI magnitude in a high risk cohort of 162 ...

Hematological malignancies account for approximately 9.5% of new cancers diagnosed annually. Lymphoma is the most frequent of all known categories of hematological malignancies. Worldwide, extensive research has focused on this type of cancer. However, new treatments are investigated in various clinical as well as pre-clinical studies. Hematopoietic stem cell transplantation (HSCT) is a recent ...

The present study reports the effect of Spirulina on radiation induced hematological and biochemical alterations in Swiss albino mice. Animals of Group-I (Control, radiation alone) were exposed to gamma radiation (8 Gy), while, animals of Group-II (Experimental, Spirulina + Radiation), received Spirulina (800 mg/kg body weight) for seven consecutive days and were exposed to gamma radiation (as ...

Background: The bone marrow examination is important for the investigation, diagnosis, and managementof blood, many systemic disorders. Morphological Bone alone issufficient to diagnose nutritional anemias most acute leukemia.This study aimed determine importance of morphological diagnosehematological non-hematological disorders like various illnesses that affect marrow.Methods: A prospective c...

A dry tap obtained on bone marrow aspiration is considered a failure to aspirate particles. However, it often related an underlying pathology that hinders successful of hematopoietic cells. In this retrospective analysis, 2768 aspirates and trephine biopsies were reviewed. Of these, 223 patients with aspirations which yielded no particles (dry tap) included in the study. Patients whom adequate ...

Background: Workers in different occupational positions experience significant Cu exposures, however, Cu toxicity has not been fully studied as compared to other heavy metals. In the present study, hematological and hepatic alterations have been investigated among copper mine workers. Materials and Methods: This descriptive study was conducted in a copper mine in west of Iran, on 402 copper mi...

Background: Microalgae are known to have beneficial effects on health. On the other hand, studies have reported negative effects of diabetes on hematological parameters. Effects of Spirulina platensis (SP) and Chlorella vulgaris (CV) microalgae, singly and combined, on hematological parameters in diabetic rats are not still studied. Thus, the present study was conducted to investigate the effec...

Patients with inherited bleeding disorders are rare in obstetric practice but present with prolonged bleeding even after minor invasive procedures. They require a combined approach with obstetric and hematological management of each case, including the neonatal management of a possibly affected fetus. We present the case of a pregnancy in a patient with combined Factor VII deficiency and Glanzm...

Canine ehrlichiosis which becomes widespread worldwide is generated by a pathogen bacteria called Ehrlichia Canis. The prevalence of ehrlichiosis changes according to geographic regions in veterinary practice. The aim of this study was to determine the prevalence of the canine ehrlichiosis in Uşak, Turkey, together with clinical, hematological and biochemical signs. 100 dogs found in 6 differen...