نتایج جستجو برای: heme oxygenase
تعداد نتایج: 23033 فیلتر نتایج به سال:
Interleukin-1β (IL-1β) activates the production of reactive oxygen species (ROS) and secretion of MMPs as well as chondrocyte apoptosis. Those events lead to matrix breakdown and are key features of osteoarthritis (OA). We confirmed that in human C-20/A4 chondrocytes the NADPH oxidase Nox4 is the main source of ROS upon IL-1β stimulation. Since heme molecules are essential for the NADPH oxidase...
An iron-containing, tetrapyrrole ring, heme is an essential prosthetic group in an array of proteins that comprehensively affect cellular function and metabolism; yet "free" heme in sufficient amounts can be damaging to the kidney and other organs because of its bioreactivity and pro-oxidant effects. This review discusses the cellular metabolism of heme in health and disease and covers such are...
College of Pharmacy and WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742, South Korea, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan, Department of Food and Nutrition, Sungsin Women’s University, Seoul 136-742, South Korea, Graduate School of Bioscience a...
With the increasing demand for blood transfusions, production of human hemoglobin (Hb) from sustainable sources is increasingly studied. Microbial an attractive option, as it may provide a cheap, safe, and reliable source this protein. To increase by yeast Saccharomyces cerevisiae, degradation Hb was reduced through several approaches. The deletion genes HMX1 (encoding heme oxygenase), VPS10 re...
Obesity is a global epidemic and a common risk factor for endothelial dysfunction and the subsequent development of diabetes mellitus and vascular diseases such as hypertension. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-derived metabolites of arachidonic acid that contribute to vascular protection by stimulating vasodilation and inhibiting inflammation. Heme oxygenase-1 is a st...
BACKGROUND It is well established that physical exercise continues to be one of the most valuable forms of non-pharmacological therapy against diabetes mellitus; however, the precise mechanism remains unknown. The aim of this study was to investigate the cardioprotective effect of voluntary exercise in the Goto-Kakizaki type 2 diabetic rat heart against ischemia-reperfusion injury and to clarif...
To analyze that glaucocalyxin B can alleviate dyskinesia, inflammatory response and oxidative stress in Parkinson's disease model rats by activating the nuclear factor erythroid 2–related 2/heme oxygenase-1 pathway. 150 adults were divided into 5 groups, namely, sham operation group (healthy mice), low-dose (Parkinson+20 ng/ml) B), medium-dose (Parkinson+40 ng/ml B) high-dose (Parkinson+60 B). ...
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