BACKGROUND AND PURPOSE We created a distal internal carotid artery side-wall aneurysm model in dogs and compared its geometric, hemodynamic, and histological similarities with human models. METHODS Eight distal internal carotid artery-shaped devices were constructed using rapid prototyping, and 8 aneurysms were created via surgical reconstruction and elastase incubation. The geometric and hem...

Many cognitive paradigms require self-paced responses or examine events that occur at unpredictable times. To explore whether functional MRI (fMRI) can accommodate such paradigms, a method allowing rapid, unpredictable trial pacing was developed and tested on 17 subjects using activation of the motor network as a model. Trial onset was determined solely by the subjects' self-paced responses and...

We aimed to investigate hemodynamic, microcirculatory and hemorheological consequence of infrarenal or suprarenal 10 aortic cross-clamping (IRAXC, SRAXC) in the rat. We hypothesized that the magnitude of the changes are different. Twenty-one 11 male rats were randomized into Control, IRAXC or SRAXC groups. Under anesthesia the right carotid artery was cannulated 12 for monitoring heart rate and...

Background: Cardiac output (CO) is the total volume of blood pumped by the heart per minute and is a function of heart rate and stroke volume. CO is one of the most important parameters for monitoring cardiac function, estimating global oxygen delivery and understanding the causes of high blood pressure. Hence, measuring CO has always been a matter of interest to researchers and clinicians. Sev...

background: prolonged qt interval may lead to serious arrhythmias and ventricular fibrillation, hence prevention of the qt-interval prolongation is crucial for physicians. the aim of this study was to assess the influence of intravenous lidocaine on the qtc interval resulting from spinal anesthesia with bupivacaine. methods: in a randomized double blind trial, fifty male patients with mean age ...

conclusions both dexmedetomidine and esmolol can be used as agents to control hypotension in patients undergoing lumbar spine decompression and fixation surgery; the dexmedetomidine group, however, was associated with better intraoperative hemodynamic stability and reduced intraoperative analgesic and volatile anaesthetic requirement. results the study results showed that dexmedetomidine had lo...