Sickle cell hemoglobinopathy Malaria Severity

A semi-quantitative method of estimating the number of target cells in blood films has been developed. It has been applied to 250 films from normal persons, pregnant women, and patients with a variety of haemoglobinopathies. Allowing for the frequency of target cells found in normal films the results show that such an examination is of value in eliminating or suggesting certain haemoglobinopath...

Blood HbA1c determination is a powerful tool for the evaluation and management of patients with diabetes mellitus. Many HbA1c analytical methods demonstrate bias in samples from patients with hemoglobinopathies. This study evaluated the analytical performance of Roche Diagnostics' 1st and 2nd generation HbA1c assays in patients with or without hemoglobinopathies whose HbA1c levels were elevated...

Objectives 1. Describe different combinations of normal and abnormal hemoglobins and their phenotypic expression 2. Describe the pathophysiology of vasooclusion secondary to hemoglobinopathies 3. Define and describe hand-foot syndrome 4. Describe features of osteomyelitis secondary to sickle cell disease and its differentiation from bone infarct 5. Describe features of avascular necrosis of bon...

collected into the sodium citrate-containing tube, which showed normal platelet counts. Only a few cases of PGPS have been reported [1-4]. To our knowledge, this is the first case to be reported in Korea. Stavem and Berg [1] described EDTA-induced ‘platelet stain preventing factor’, and Mant et al. [2], Cockbill et al. [3], and Toyota et al. [4] reported platelet degranulation caused by EDTA. U...

BACKGROUND Newborn screening (NBS) for hemoglobinopathies facilitates early identification of affected individuals to ensure the prompt institution of comprehensive medical care for affected newborns in California. When linked to extensive follow-up and education, NBS has been shown to significantly reduce mortality in children with sickle cell disease. Due to changing immigration patterns from...

Prenatal diagnosis of β-thalassemia was accomplished for the first time in the 1970s by globin chain synthesis analysis on fetal blood obtained by placental aspiration at 18-22 weeks gestation. Since then, the molecular definition of the β-globin gene pathology, the development of procedures of DNA analysis, and the introduction of chorionic villous sampling have dramatically improved prenatal ...

nificant lengthening of PFS was the result of IFN maintenance therapy, as already reported.10 Our experience, although limited, confirms the efficacy of purine analogs as second line therapy. In agreement with Rai et al.8 the very high projected survival probability of our series can be explained mainly by a two step therapeutic strategy made up of IFN first line therapy and purine analog salva...

background: beta thalassemia gene mutations are among common mutations in southwest iran. however, hemoglobin e (hb e) and hb e/β⁰ thalassemia account for a small number of hemoglobinopathies in iran. this is the first study to directly address the existence of hb e and consequently hb e/β⁰ thalassemia in southwest iran. methods: this retrospective study discovered seven cases of hb e/β⁰ thalas...