sixty-six children with g6pd deficiency were evaluated retrospectively to ascertain the clinical features, etiology, ultimate outcome and population at risk, the occurrence of jaundice in 18 neonates (group j) was, contrary to other countries, in the form of neonatal jaundice type ii. sepsis, prematurity, hypoxia and acidosis were associating factors. 77.8% of neonates had exchange blood transf...

INTRODUCTION Hemolytic disease of the fetus and newborn is most commonly caused by anti-D alloantibody. It is usually seen in Rhesus D (RhD)-negative mothers that have been previously sensitized. We report here a case of hemolytic disease of the fetus and newborn in a newborn baby caused by anti-D and anti-S alloantibodies, born to a mother who was RhD negative, but with no previous serological...

BACKGROUND Etiology of cholestatic liver disease in neonates with hemolytic disease of the newborn (HDN) has been associated with iron overload due to intrauterine red cell transfusions (IUTs). Data on the incidence and severity of cholestasis in neonates with HDN are scarce, and little is known about pathogenesis, risk factors, neonatal management and outcome. OBJECTIVE To evaluate incidence...

FINCA (Fibrosis, Neurodegeneration, Cerebral Angiomatosis) syndrome is a new genetic multiorgan disease caused by mutation in NHLRC2 (NHL repeat-containing protein 2). Disease manifests at an early age interstitial lung disease, neurodegenerative disorders, hemolytic anemia, gastrointestinal liver dysfunction and other changes. The was first described 2018 three children who died before the of ...

By Bm N S. Bin L AND IRvIN N. KUHN A FORM OF HEMOLYTIC ANEMIA characterized by thrombocytopenia and the presence of fragmented red cells in the peripheral blood has been called microangiopathic hemolytic anemia by Brain, Dacie and Hourihane.’ These workers showed that in this disease the amount of hemoglobinemia and the degree of erythrocyte fragmentation correlated closely with the severity of...

By Bm N S. Bin L AND IRvIN N. KUHN A FORM OF HEMOLYTIC ANEMIA characterized by thrombocytopenia and the presence of fragmented red cells in the peripheral blood has been called microangiopathic hemolytic anemia by Brain, Dacie and Hourihane.’ These workers showed that in this disease the amount of hemoglobinemia and the degree of erythrocyte fragmentation correlated closely with the severity of...

By Bm N S. Bin L AND IRvIN N. KUHN A FORM OF HEMOLYTIC ANEMIA characterized by thrombocytopenia and the presence of fragmented red cells in the peripheral blood has been called microangiopathic hemolytic anemia by Brain, Dacie and Hourihane.’ These workers showed that in this disease the amount of hemoglobinemia and the degree of erythrocyte fragmentation correlated closely with the severity of...

Introduction Chronic granulomatous disease (CGD) is a primary immune deficiency that characterized with recurrent infections and granuloma formation. A variety of autoimmune disorders and immune-mediated phenomena such as inflammatory bowel disease, discoid lupus erythematous, juvenile idiopathic arthritis, Ig A nephropathy, sarcoidosis, rheumatoid arthritis, idiopathic thrombocytopenia, eosino...

RhD antigen is the most immunogenic and clinically significant antigen of red blood cells after ABO system. It has historically been associated with hemolytic disease of the newborn (HDN) which is now routinely prevented by the administration of polyclonal anti-D immunoglobulin. This management of HDN has proven to be one of the most successful cases of prophylactic treatment based on antibody ...

We previously described a simplified quantitative hemolytic assay for classical pathway (CP) hemolytic function in serum that has been shown to correlate with the 50% hemolytic complement (CH50) assay. In the present study, we used this assay to compare CP functions; plasma levels of C3, C4, and C3dg; and ratios of C3dg to C3 in healthy individuals and patients with systemic lupus erythematosus...