The liver is involved in the synthesis and metabolism of many kinds of hormones, various abnormalities hormone levels are found in advanced liver disease. For example the liver is, extremely sensitive to changes in insulin or glucagon levels. The liver is the primary organ of iron storage is frequently involved, diabetes is common in patients with iron overload and may be seen in cirrhosis. Chr...

Peripheral blood and hepatic tissue T- and B-lymphocyte distributions, serum alpha fetoprotein (AFP) concentrations, and hepatic AFP were studied in 46 patients undergoing diagnostic percutaneous liver biopsy. The patients included 26 with alcoholic liver disease, 13 with nonalcoholic hepatitis or cirrhosis, and 7 with either normal histology or minor nonspecific changes. Serum AFP was determin...

Cirrhosis has traditionally been considered an irreversible process of end-stage liver disease. With new treatments for chronic disease, there is regression fibrosis and cirrhosis, improvement in clinical parameters (i.e. function hemodynamic markers, hepatic venous pressure gradient), survival rates, demonstrating that fibrolysis are a dynamic moving two directions. Microscopically, hepatocyte...

The aim of this study was to evaluate the meaning of laparoscopic splenomegaly and its relationship with the severity and evolution of liver cirrhosis. Medical records of 2,525 consecutive patients with chronic liver diseases who underwent laparoscopy and video-guided hepatic biopsy were reviewed. There were 1,610 (63.8%) men and 915 (36.2%) women. All patients underwent gastroscopy to diagnose...

BACKGROUND/AIMS Data on the epidemiology of alcoholic cirrhosis, especially in Asian countries, are limited. We compared the temporal evolution of patterns of alcoholic and nonalcoholic cirrhosis over the last decade. METHODS We retrospectively examined the inpatient datasets of five referral centers during 2002 and 2011. The study included patients who were admitted due to specific complicat...