نتایج جستجو برای: hepatic stellate cell
تعداد نتایج: 1763684 فیلتر نتایج به سال:
BACKGROUND/AIMS Profibrogenic TGF-beta signaling in hepatic stellate cells is modulated during transdifferentiation. Strategies to abrogate TGF-beta effects provide promising antifibrotic results, however, in vivo data regarding Smad activation during fibrogenesis are scarce. METHODS Here, liver fibrosis was assessed subsequent to bile duct ligation by determining liver enzymes in serum and c...
Diminished endothelial nitric oxide (NO) synthase (eNOS)-derived NO production from the hepatic vascular endothelium contributes to hepatic vasoconstriction in portal hypertension. The aim of this study was to examine the mechanism of this process by testing the influence of a constitutively active form of eNOS (S1179DeNOS) in both primary and propagated liver cells in vitro and in the sham and...
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