Neuropathic pain may result from a wide spectrum of insults to the peripheral or central nervous system. This may include nutritional deficiencies, systemic diseases, chemotherapy, cerebrovascular accident, surgery or trauma. The hallmark of neuropathic pain is abnormal neural activity in peripheral nerve(s) or the central nervous system. This is often accompanied by disordered sensory processi...

Neuropathic pain is a severe health problem for which there is a lack of effective therapy. A frequent underlying condition of neuropathic pain is a sustained overexcitability of pain-sensing (nociceptive) sensory fibres. Therefore, the identification of mechanisms for such abnormal neuronal excitability is of utmost importance for understanding neuropathic pain. Despite much effort, an inclusi...

OBJECTIVE Pain medicine still lacks mechanism-specific biomarkers to guide diagnosis and treatment, and defective top-down modulation is an important factor in the pathophysiology of chronic pain conditions. Using modern analytical tools and advanced multivariate statistical analysis, the aim of this study was to revisit two classical potential biomarkers of pro- and anti-nociception in humans ...

Neuropathic pain, defined as pain caused by a lesion or disease of the somatosensory nervous system, is characterized by dysesthesia, hyperalgesia, and allodynia. The number of patients with this type of pain has increased rapidly in recent years. Yet, available neuropathic pain medicines have undesired side effects, such as tolerance and physical dependence, and do not fully alleviate the pain...

Emerging evidence from animal models of neuropathic pain suggests that many pathophysiologic and biochemical changes occur in the peripheral and central nervous system. Similarities between the pathophysiologic phenomena observed in some epilepsy models and in neuropathic pain models justify the use of anticonvulsants in the symptomatic management of neuropathic pain. Positive results from labo...

background and objectives: cucurbita pepo l. is a one-year creeper plant with wide heart shaped leaves covered by tiny trichome with many benefits in its fruit, seed, leaf and root. currently some studies has been directed to show its preventive and curetive properties for some diseases as an alternative or supplement for other methods. the purpose of present study was to investigate the mentio...

background: rosa canina l. (rose hip) has been traditionally used to treat diabetes mellitus in iran. however, no scientific human study has determined its efficacy in diabetic patients. objective: this study was conducted to evaluate the efficacy and safety of r. canina fruit aqueous extract in type 2 diabetic patients. methods: sixty patients with type 2 diabetes, aged 35 - 60 years with fast...

considering the clarification of negative effects of chemical medicine on human beings, tendency to use herbal medicine has been increasing. herbal medicines provide an important alternative to health the conventional medicines. the combination therapy, using both herbal medicine and conventional medicine, caused the herbal medicine to become more important than ever before. the present study e...

objective(s):based on the previous reports, silymarin can suppress nitric oxide, prostaglandin e2 (pge2), leukotrienes, cytokines production, and neutrophils infiltration. regarding the fact that inflammation plays an important role in neuropathic and formalin-induced pain, it was assumed that silymarin could reduce pain. the present study investigates the analgesic effects of silymarin in chem...

Disorders of the somatosensory system such as neuropathic pain are common in people with chronic neurologic and musculoskeletal diseases, yet these conditions remain an underappreciated morbidity in veterinary patients. This is likely because assessment of neuropathic pain in people relies heavily on self-reporting, something our veterinary patients are not able to do. The development of neurop...