cronkhite- canada syndrome (ccs) considered as a rare and non-hereditary disorder. gastrointestinal polyposis and diarrhea along with some extra signs and symptoms such as hypoproteinemia, and epidermal manifestations are recognized in this syndrome. the pathophysiology of this syndrome is not completely understood and it seems that inflammatory processes may be involved. we present a 50 year-o...

The primary study objectives were to estimate the frequencies and rates of gastrointestinal bleeding and peptic ulcerative disorder in HIV-positive patients compared with age- and sex-matched HIV-negative subjects. Data from a US insurance claims database was used for this analysis. Among 89,207 patients with HIV, 9.0% had a GI bleed, 1.0% had an upper gastrointestinal bleed, 5.6% had a lower g...

The article represents a review of recent data about the therapy of von Willebrand disease in children and adolescents (hereditary as well as acquired forms of the disease). The treatment of bleeding events in these patients, the indications in different subtypes, and the future lines of research are mentioned.

The study aim was to develop an algorithm supporting decision-making at the Hospital Emergency Department or Admission Room for management of unexpected bleeding suggestive a disorder.

Pediatric emergency visits with purpura fulminans should raise the suspicion of hereditary homozygous protein C deficiency even beyond the neonatal age. The absence of this classical finding does not role the diagnosis out as atypical presentation with isolated intraocular bleeding was observed. Premarital counseling should be offered when family history suggests.

Bevacizumab has become a frequently used therapeutic option for bleeding complications in hereditary hemorrhagic telangiectasia (HHT). Renal limited thrombotic microangiopathy is a welldocumented complication of Bevacizumab therapy. We present an unusual case of Bevacizumab induced thrombotic microangiopathy complicated by glomerular predominant renal hemosiderosis in a patient with HHT-associa...

OBJECT Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal-dominant vascular dysplasia with a high prevalence of cerebrovascular malformations (CVMs), mostly manifested as arteriovenous malformations (AVMs). The natural history and bleeding risk of these CVMs is unknown. The authors investigated the risk of bleeding in conjunction with clinical and radiological features in patients ...

Although non-melanoma skin cancers are the most predominant malignancies in the Caucasian population and hemophilia A is one of the most frequent hereditary bleeding disorders, medical literature data about the management of non-melanoma skin cancers in patients with hemophilia are surprisingly scarce. In this case report we describe the treatment of a patient with multiple recurrent non-melano...

this syndrome is a genetical disorder with symptoms result from deficit in the formation of connective tissue, especially collagen fiber biosynthesis. in these patients, there is hyperelasticity and fragility of the skin and mucosa. injuries sever bleeding, internal bleeding and hemartrosis may be seen in these patients. wounds leave scars after healing. there is recurrent dislocation of the jo...