No abstract available.

José Rizal (1861-1896) is one of the most revered figures in Philippine history. He was a multifaceted intellectual and a political activist, best known for his political writings that inspired the Philippine revolution and ultimately led to his execution by the Spanish colonizers. Rizal was also a physician who trained in ophthalmology under 2 prominent European ophthalmologists, Louis de Weck...

150 years ago last month, The Lancet published an obituary: " DR JOHN SNOW—This well-known physician died at noon on the 16th instant, at his house in Sackville-street, from an attack of apoplexy. His researches on chloroform and other anaesthetics were appreciated by the profession. " John Snow's death was sudden and early—he was only 45 years of age. Other obituaries and eulogies were more ef...

This Focus Issue explores autophagic responses to stress in cardiometabolic disease, reveals how autophagy limits pathological hypertrophy in the heart, and describes how autophagy itself can regulate transcriptional responses to stress.

In this paper, we present a hero recommendation engine for the popular computer game Dota 2. We detail previous efforts at hero recommendation, building on these to provide a more complete exploration of machine learning algorithms applied to this problem. In addition to discussing the details behind the machine learning algorithms we use, we also provide insight into our method of data collect...

The purpose of this study was to evaluate the efficiency of ProFile, GT, ProTaper, Race and K3 rotary instruments compared with hand K-files for removal of gutta-percha during retreatment. Sixty mandibular premolars were instrumented with GT rotary files and filled by thermomechanical compaction of gutta-percha and AH Plus sealer. The teeth are randomly divided into 6 groups of 10 specimens eac...

The idea behind the YouHero was two-fold: First, to make an expressive instrument out of the computer game toy guitar controller from the famous game GuitarHero. With its limited amount of control parameters, this was a challenge. Second, we wanted to provide an alternative to the view that you become a hero by perfect imitation of your idols. Instead, play yourself. You are the hero. In this p...

The current study explores the roles offenders see themselves playing during an offence and their relationship to different crime types. One hundred and twenty incarcerated offenders indicated the narrative roles they acted out whilst committing a specific crime they remembered well. The data were subjected to Smallest Space Analysis (SSA) and four themes were identified: Hero, Professional, Re...