Of the two virologically distinct types of Herpes simplex viruses i.e., types 1 and 2, Herpes simplex virus-2 [HSV-2] is the predominant cause of neonatal disease, and is almost always acquired from an infected maternal genital tract. Perinatally transmitted HSV-2 infection in the neonate may have either a localized, disseminated or encephalitic pattern of presentation. The encephalitic from of...

Earlier reports have described a novel protein kinase in cells infected with herpes simplex or pseudorabies viruses. These novel enzymes were characterized by their acceptance of protamine as a substrate and by their differential chromatographic behavior in anion-exchange chromatography. We report that this activity was not present in extracts of uninfected cells or of cells infected with a mut...

abstract: herpes simplex encephalitis (hse) is a life threatening outcome of herpes simplex virus (hsv) infection of the central nervous system (cns). hsv accounts for 2-5 percent of all cases of encephalitis. one third of cases occur in those younger than 20 years old and one half in those older than 50 years old. clinical diagnosis is recommended in the encephalopathic, febrile patients with ...

The propagation of viruses in cultures of mammalian tissue cells provides many new applications and advantages for virus research and routine diagnostic work. Although herpes simplex virus has been propagated in tissue culture by several workers (literature reviewed by Sanders, Kiem and Lagunoff, 1953), there still exists a need for a simple method which will produce high yields of virus and gi...

86 patients with lymphoma were evaluated prospectively for clinical and laboratory evidence of recurrent varicella-zoster, herpes simplex, and cytomegalovirus infections during the first 16 mo of treatment. Cellular immunity to the viral antigens was measured by in vitro lymphocyte transformation and interferon production. Antibody titers and nonspecific measures of cellular immunity, including...

OBJECTIVE To report the frequency of coexisting herpes viruses (herpes simplex virus 1 [HSV-1] or HSV-2, varicella zoster virus, Epstein-Barr virus [EBV], cytomegalovirus, or human herpes virus 6 [HHV-6]) and autoantibodies in patients with encephalitis (herpes or autoimmune) in clinical laboratory service. METHODS Three groups were evaluated for herpes viruses and antibodies: group 1-patient...

    Acyclovir (9-[2-hydroxyethoxymethyl] guanine) is an acyclic nucleoside analogue of guanosine which is a potent and selective antiviral agent. Acycloviris converted to the monophosphate by thymidine kinase the virus-specific form of this enzyme and is subsequently converted to the triphosphate by the host cell kinase. Acyclovir triphosphate inhibits viral DNA-polymerase terminating the chain...

Sexually transmitted diseases (STDs) are caused by organisms that infect the mucosal surfaces of the genitourinary tract. In spite of its public health importance, particular scientific problems have delayed the development of an STD vaccine, such as incomplete attenuation (human herpes simplex virus type 2), accentuated immunopathology (Chlamydia trachomatis), poor immunogenicity (Treponema pa...

Copyright: © 2013 Dreyfus DH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Recurrent or severe infection with Herpes Viruses may reflect an acquired underlying immune deficiency such as AIDS/HIV-1 infection...

Inflammasome activation is exclusively involved in sensing of innate immunity and inflammatory response during viral infection. Accumulating evidence suggests that the manipulation inflammasome assembly or its interaction with proteins are critical factors pathogenesis. Results from pilot clinical trials show encouraging results NLRP3 suppression reducing mortality morbidity SARS-CoV-2-infected...