SCOEL has already issued Summary Documents on both Lead and Lead Compounds (SCOEL/SUM 83) and Hexavalent Chromium Compounds (SCOEL/SUM 86), to which reference is made. On this basis, the present Summary Document on Lead Chromate is focussed on experimental data on the genotoxicity of lead chromate and on the issue of bioavailibility. Specific data on lead chromate published after the latest IAR...

..................................................................................................................................... ix Chapter 1 : Introduction .............................................................................................................. 1 1.1 Chapter 1 References ....................................................................................................

SCOEL has already issued Summary Documents on both Lead and Lead Compounds (SCOEL/SUM 83) and Hexavalent Chromium Compounds (SCOEL/SUM 86), to which reference is made. On this basis, the present Summary Document on Lead Chromate is focussed on experimental data on the genotoxicity of lead chromate and on the issue of bioavailibility. Specific data on lead chromate published after the latest IAR...

SIR,-Epidemiological evidence implicates chromium as a possible carcinogen that is responsible for nasal and lung tumours encountered in industries dealing with the extractions of chromium from its ore, with chromium plating or with chromium pigments etc. (for references see International Agency Research Cancer Monographs, 1973; Langard and Norseth, 1975). Yet, when various chromium preparation...

High levels of hexavalent chromium (Cr(VI)) in groundwater are typically attributed to anthropogenic sources. However, scientific reports over the last decade have demonstrated that relatively high levels of Cr(VI) in groundwater may also be due to natural processes. Cr(VI) is among the most significant groundwater contaminants, since it is a potential carcinogenic compound that is commonly fou...

Induction of DNA damage by carcinogenic hexavalent chromium compounds [Cr(VI)] results from its reduction to lower oxidation states. Reductive metabolism of Cr(VI) generates intermediate Cr(V/IV)species, organic radicals, and finally Cr(III), which forms stable complexes with many biological ligands, including DNA. To determine the biological significance of different reaction products, we exam...