The development left ventricular hypertrophy (LVH) represents a critical milestone in patients with hypertensive heart disease (HHD). This structural remodeling and the associated abnormalities in diastolic function portend an increased risk of both mortal and morbid events (1–4). Treatment that results in the regression of LVH is associated with a reduction in these event rates (5–8). However,...

Peptides presented by HLA-A*0201 molecules on the surface of the human breast carcinoma cell line KS24.22 after IFN-g induction were analyzed by the “Predict-Calibrate-Detect” approach, which combines epitope prediction and high-performance liquid chromatography mass spectrometry. One of the predicted epitopes, MAGE-A1278–286 (KVLEYVIKV), was found to be presented by HLA-A*0201, with an estimat...

BACKGROUND We investigated whether increased collagen type I synthesis and deposition contribute to enhancement of myocardial fibrosis and deterioration of cardiac function in patients with hypertensive heart disease (HHD). METHODS AND RESULTS We studied 65 hypertensives with left ventricular hypertrophy subdivided into 2 groups: 34 patients without heart failure (HF) and 31 patients with HF....

The main objective of this study was to determine the concurrent validity between a hand-held (HHD) and mounted dynamometer (MHHD) for assessing isometric neck strength. Observational design. Semiprofessional rugby club. Nineteen semi-professional players (age = 26 ± 5 years, stature 186.5 6.5 cm, body mass 98.7 12.8 kg). Concurrent (limits agreement, correlation) HHD MHHD, intrarater reliabili...

Abstract Augmented reality (AR) is a technology that allows overlaying of virtual elements on top the physical environment. This enhances perception and conveys additional information to user. With emergence industry 4.0 concepts in manufacturing landscape, AR found its way improve existing Human-Machine Interfaces (HMI) shop-floor. The industrial setting has wide variety application opportunit...

Üst ekstremite hareketi tam olarak sağlanamadığında, yapay zeka (artificial intelligence/AI) sistemleri kullanıcılara amaçlanan hareketin uygulanması konusunda yardımcı olurlar. Kas aktivitesinin temsili olan elektromiyografi (EMG), sanal gerçeklik uygulamaları ve protez kontrolleri gibi AI-tabanlı sistemlerde kullanıldığında çeşitli faydalar sağlar. Bu çalışmada, bahsedilen sistemlere etkin ko...

Background: The Transversus Abdominis Plane (TAP) block technique is one method for inhibiting abdominal pain stimuli by blocking afferent nerves in the wall via Petit triangle. TAP action frequently performed as a postoperative procedure, such case of hernia repair. goal using ultrasound blocks to distribute anesthetic agent accurately appropriate neurovascular plane. Case: A 66-year-old male ...

The influenza A nucleoprotein (NP) is an attractive target for avian flu vaccine development because of its high conversancy in the evolutionary chain of the virus. Here we identified two novel HLA-A*0201 restricted NP epitopes, named H5N1 NP373-381 AMDSNTLEL (NP373) and NP458-466 FQGRGVFEL (NP458), using computational bioinformatic analysis. The NP peptides showed a high binding affinity to HL...

BACKGROUND Specific cellular cytotoxic immune responses (CTL) are important in combating viral diseases and a highly desirable feature in the development of targeted HIV vaccines. Adjuvants are key components in vaccines and may assist the HIV immunogens in inducing the desired CTL responses. In search for appropriate adjuvants for CD8(+) T cells it is important to measure the necessary immunol...

1. Two novel HLA-A2.1 specific H5N1 nucleoprotein epitopes(NP373-381 AMDSNTLEL and NP458-466 FQGRGVFEL) capable of activating cytotoxic T-cells in vitro were identified. 2. When the H5N1 nucleoprotein epitopes (NP373-381AMDSNTLEL and NP458-466FQGRGVFEL) were used with the single chain trimer system, they elicited effective cytotoxic T-cell responses against the corresponding nucleoprotein pepti...