This study evaluated immunomodulatory properties and the sub-acute toxicity profile of two fractions of the aqueous alcoholic extract of the dried calyx of Hibiscus sabdariffa in experimental animals. Immunomodulatory activity was evaluated using red blood cell-induced immunostimulation. The fractions were not found to be toxic after 7-day administration, though there was severe weight loss wit...

The aqueous calyx extract of Hibiscus sabdariffa (HS) has a folk reputation as an antihypertensive agent. On account of its antioxidant properties and probably high K+ concentration, we hypothesized that HS may attenuate the development of salt-induced hypertension. Sprague-Dawley rats (n=8 each) were treated for 12 weeks as follows: control (normal diet + water), salt-loaded (8% salt diet + wa...

The effects of aqueous extract of Hibiscus sabdariffa calyces on haematology and pathological changes in some selected organs during experimental Trypanosoma congolense infection of rats were investigated. Three groups of rats were intraperitoneally infected with T. congolense (Karu stock). One group was administered with the aqueous extract and another given a solution of vitamin C in drinking...

Introduction Diabetes mellitus is a chronic metabolic disease which involves nearly all organs of human body, and is an important challenge of healthcare system in throughout the world. It is a prominent risk factor for cardiovascular disorders such as hypertension and atherosclerosis, renal failure, neuropathies, eye and skin complications. Hyperglycemia induced over production of reactive spe...

Seed dispersal provides a template upon which the demographic processes of plant life cycles operate and, most importantly, seed dispersal determines the spatial distribution of genetic variation. Here, we review recent studies on seed dispersal by water (hydrochory) in species of Hibiscus to elucidate the potential ecological and evolutionary consequences of hydrochory at different spatiotempo...

The Hibiscus cannabinus (H. cannabinus) seed is used for curing male infertility and impotency in traditional medicine. However, the validity has not been scientifically evaluated. Therefore, the present study was undertaken to evaluate the effect of H. cannabinus seed on the sexual behaviour of male rats. Sixty six rats were randomized into five groups and were treated as one control group, th...

The effects of a 90-day oral administration of water and alcohol extracts of dried calyx of Hibiscus sabdariffa were evaluated in albino rats. Haematological, biochemical and histopathological changes were monitored every 30 days.The death of the animals was preceded by a severe loss in weight, accompanied with diarrhoea in animals on the 2000 mg/kg dose. There was an increase in food intake (g...

Doxorubicin (DOX) is an effective anticancer drug. But its clinical application is limited, because DOX induces apoptosis in cardiomyocytes and it leads to permanent degenerative cardiomyopathy and heart failure. Recent trainings showed that Hibiscus sabdariffa exhibit pharmacological actions such as potent antioxidant. So, in this study we explored the protective effect of H. sabdariffa extrac...

The Hibiscus sabdariffa calyxes' residue (HSR) remained after the extraction of beverage is discarded which contributes to environmental pollution. The objective of this study was to explore the suitability of incorporating different amount of HSR (0%, 1.25%, 2.5%, 3.75%, and 5.0%) in crackers to enhance dietary fiber and antioxidant content. Physicochemical properties, antioxidants activity, n...