OBJECTIVE To compare cardiac troponin T release and lactate metabolism in coronary sinus and arterial blood during uncomplicated coronary grafting on the beating heart with conventional coronary grafting using cardiopulmonary bypass. DESIGN A prospective observational study with simultaneous sampling of coronary sinus and arterial blood: before and 1, 4, 10, and 20 minutes after reperfusion f...

BACKGROUND Troponin-T elevation is seen commonly in sepsis and septic shock patients admitted to the intensive care unit. We sought to evaluate the role of admission and serial troponin-T testing in the prognostication of these patients. METHODS AND RESULTS This was a retrospective cohort study from 2007 to 2014 on patients admitted to the intensive care units at the Mayo Clinic with severe s...

Cardiac troponin T (cTnT) and troponin I (cTnI) are cardiac regulatory proteins that control the calcium mediated interaction between actin and myosin [1]. The troponin complex consists of three subunits: troponin C, troponin I, and troponin T. This complex is located on the myofibrillar thin (actin) filament of striated (skeletal and cardiac) muscle. The cardiac isoforms troponin T and I are o...

Sir, M of myocardial necrosis have gone through a long journey since 1950s.The cardiac biomarkers(CB) of past include total creatine kinase (CK) activity, aspartate aminotransferace activity (AST), lactate dehydrogenase (LDH) and LD1/LD2 ratio while the current CB are CK-MB, myoglobin, CKMB isoforms, cardiac troponin (cTn) I and T. The introduction of heart –type fatty–acid binding protein (H-F...

The first Cardiac Emergency Room (CER) was founded in 1978 by Professor Dirk Durrer in Amsterdam. CERs have since then been opened in many countries, with the initial goal of reducing time delays in patients with acute myocardial infarction. In this role they have contributed to the reductions in mortality from coronary disease that have been observed in the past decades [1]. In later years, th...

Cardiac troponin T (cTnT) and troponin I (cTnI) are cardiac regulatory proteins that control the calcium mediated interaction between actin and myosin [1]. The troponin complex consists of three subunits: troponin C, troponin I, and troponin T. This complex is located on the myofibrillar thin (actin) filament of striated (skeletal and cardiac) muscle. The cardiac isoforms troponin T and I are o...