نتایج جستجو برای: hind limb tonic extension

تعداد نتایج: 232704  

2011
Nikhlesh K. Singh Venkatesh Kundumani-Sridharan Gadiparthi N. Rao

To understand the mechanisms by which 15(S)-hydroxyeicosatetraenoic acid (15(S)HETE) activates Rac1 in the induction of angiogenesis, we studied the role of 3-hydroxy-3-methylglutaryl–coenzyme A (HMG-CoA) reductase and Pix. 15(S)-HETE stimulated Rac1 in a sustained manner in human dermal microvascular endothelial cells (HDMVECs). Simvastatin, a potent inhibitor of HMG-CoA reductase, suppressed ...

Journal: :Canadian journal of physiology and pharmacology 2017
Yan-Jun Xu Vijayan Elimban Naranjan S Dhalla

In this study, we investigated the effects of CO2 water-bath therapy on blood flow and angiogenesis in the ischemic hind limb, as well as some plasma angiogenic factors in peripheral ischemic model. The hind limb ischemia was induced by occluding the femoral artery for 2 weeks in rats and treated with or without CO2 water-bath therapy at 37 °C for 4 weeks (20 min treatment every day for 5 days ...

Journal: :The Japanese journal of physiology 2002
Chie Sato Masahito Nemoto Mamoru Tamura

Incorporating the wavelength dependence of the scattering effect into a simple linear multicomponent analysis of intrinsic optical signals, we have reexamined the change in the hemoglobin (Hb) concentration and the origins of intrinsic signals in somatosensory cortex evoked with electrical stimulation of the hind limb (5 Hz, 2 s) of anesthetized rat. The concept of the analysis was to separate ...

Journal: :Blood 1984
P Mauch J M Lipton B Hamilton J Obbagy M Kudisch D Nathan S Hellman

The use of the bone marrow culture technique was studied as a means to prepare donor marrow for bone marrow transplantation to avoid lethal graft-versus-host disease (GVHD). Preliminary experiments demonstrated the rapid loss of theta-positive cells in such cultures, so that theta-positive cells were not detected after 6 days. Initial experiments in C3H/HeJ (H-2k, Hbbd) recipients prepared with...

2017
Guo-Dong Wang Yi-Xun Liu Xiao Wang Yong-Le Zhang Ya-Dong Zhang Feng Xue

This study aims to explore the role of the SDF-1/CXCR4 axis in mediating BMSCs and SCI recovery. BMSCs were collected and SCI rat models were established. Wistar rats were assigned into the blank control, sham, SCI, SCI + BMSCs, SCI + BMSCs + SDF-1, SCI + BMSCs + AMD3100 (an inhibitor of SDF-1/CXCR4 axis) and SCI + BMSCs + SDF-1 + AMD3100 groups. Hind limb motor function was measured 7, 14, 21 ...

2017
Ning Zhu Changhong Cai Aiming Zhou Xuyong Zhao Yijia Xiang Chunlai Zeng

Schisandrin B (ScB), isolated from Schisandra chinensis (S. chinensis), is a traditional Chinese medicine with proven cardioprotective and neuroprotective effects. However, it is unclear whether ScB also has beneficial effects on rat hind limb ischemia/reperfusion (I/R) injury model. In this study, ScB (20 mg/kg, 40 mg/kg, and 80 mg/kg) was administered via oral gavage once daily for 5 days bef...

Journal: :The Biochemical journal 1990
R G Vernon A Faulkner W W Hay D T Calvert D J Flint

1. The effects of varying the plasma insulin concentration by infusion while maintaining euglycaemia by infusion of glucose on nutrient arterio-venous differences across the hind-limb and mammary gland in lactating and non-lactating sheep were investigated. 2. Insulin infusion increased the glucose arterio-venous difference across the hind-limb; this effect of insulin was decreased by lactation...

Journal: :Clinical science 1980
S Z Langer R Massingham N B Shepperson

1. In the autoperfused hind limb of the dog prazosin (10 microgram/kg intravenously) markedly antagonized responses to lumbar sympathetic stimulation, whereas responses to injected noradrenaline were largely unaffected. 2. In beta-adrenoreceptor- and ganglion-blocked animals, the hind limb pressor responses to phenylephrine were antagonized to a greater degree by prazosin than responses to inje...

Journal: :Current Biology 2001
Karim Fouad Vera Pedersen Martin E. Schwab Christian Brösamle

The adult central nervous system (CNS) of higher vertebrates displays a limited ability for self repair after traumatic injuries, leading to lasting functional deficits [1]. Small injuries can result in transient impairments, but the mechanisms of recovery are poorly understood [2]. At the cortical level, rearrangements of the sensory and motor representation maps often parallel recovery [3,4]....

Journal: :Pharmacological reports : PR 2013
Dorota Żółkowska Mateusz Kominek Magdalena Florek-Łuszczki Sergey L Kocharov Jarogniew J Łuszczki

BACKGROUND The aim of this study was to determine the effects of N-(morpholinomethyl)-p-isopropoxy-phenylsuccinimide (MMIPPS) on the protective action of four classical antiepileptic drugs (AEDs: carbamazepine [CBZ], phenobarbital [PB], phenytoin [PHT] and valproate [VPA]) against maximal electroshock (MES)-induced seizures in mice. METHODS Tonic hind limb extension (seizure activity) was evo...

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