Hippocampal neurogenesis undergoes dramatic age-related changes. Mice with targeted deletion of the clock geneBmal1 (Bmal1(-/-)) show disrupted regulation of reactive oxygen species homeostasis, accelerated aging, neurodegeneration and cognitive deficits. As proliferation of neuronal progenitor/precursor cells (NPCs) is enhanced in young Bmal1(-/-) mice, we tested the hypothesis that this resul...

This study was designed to investigate the protective effects of the combination of guanosine and 2 organoselenium compounds (ebselen and diphenyl diselenide) against glutamate-induced oxidative stress in different regions of rat brains. Glutamate caused an increase in reactive oxygen species (ROS) generation and a decrease in [(3)H]-glutamate uptake in striatal, cortical, and hippocampal slice...

The mechanisms by which administration of interferon-alpha induces neuropsychiatric side effects, such as depressive symptoms and changes in cognitive function, are not clear as yet. Direct influence on serotonergic neurotransmission may contribute to these side effects. In addition, the enzyme indoleamine 2,3-dioxygenase (IDO), which converts tryptophan into kynurenine, may play an important r...

objective(s):the present study was undertaken to determine the effects of acute exposure to malathion on oxidative stress and cytotoxic potential of anticholinesterase insecticide, malathion in reproductive toxicology of adolescent male mice. materials and methods: thirty two adolescent male mice at pubertal age were treated with 500 mg/kg body weight (bw) of malathion for three days. after exp...

objective(s) the aim of this study was to evaluate the effects of regular exercise in preventing diabetes complication in the hippocampus of streptozotocin (stz)-induced diabetic rat. materials and methods a total of 48 male wistar rats were divided into four groups (control, control exercise, diabetic and diabetic exercise). diabetes was induced by injection of single dose of stz. exercise was...

background there is currently great concern about the possible adverse effect of microwave radiation from cell phones. in addition, noise is one of the physical pollutants of modern societies. objectives the present study aimed to examine the separate and simultaneous effects of cell phone microwaves, noise, and their effects on sperm parameters and total antioxidant capacity in adult male rats...

Background and Objective: Lipolysaccharide (LPS) is a large molecule isolated from bacteria such as the enterobacteriaceae family with a negative effect on memory and learning through disturbing the balance of free radicals and creating oxidative stress conditions. In this study, we evaluated  the effect of quercetin on oxidative stress and LPS-induced memory impairment in the rat. Materials a...

Oxidative stress is implicated in the nerve cell death that occurs in a variety of neurological disorders, and the loss of protein kinase C (PKC) activity has been coupled to the severity of the damage. The functional relationship between stress, PKC, and cell death is, however, unknown. Using an immortalized hippocampal cell line that is particularly sensitive to oxidative stress, I show that ...

objectives we aimed to investigate whether there is renal injury and its relationship with oxidative stress after intraperitoneal injection of α-ama in mice experimental poisoning models. materials and methods there were 37 male balb/c laboratory mice treated with α-ama, according to the study groups: control group (n = 7); low dose (0.2 mg/kg) (n = 10); moderate dose (0.6 mg/kg) (n = 10), and ...