(1) The pharmacology of ATP responses and the expression pattern of seven known subunits of the P2X receptor were investigated in individual histaminergic neurons of the tuberomamillary nucleus (TM). (2) ATP (3-1000 micro M) evoked fast non-desensitizing inward currents in TM neurons. 2-methylthioATP (2MeSATP) displayed the same efficacy but a lower potency, EC(50)s 84 micro M versus 48 micro M...

Tourette’s syndrome (TS) is a heritable neuropsychiatric disorder that is characterized by the display of repetitive tics. These tics are defined as sudden and recurring stereotyped vocalizations or movements. The incidence of TS includes a large environmental component as considerable phenotypic variability between monozygotic twin TS cases has been observed (1). Although TS is not associated ...

The histaminergic tuberomamillary nucleus (TMN) controls arousal and attention, and the firing of TMN neurons is state-dependent, active during waking, silent during sleep. Thyrotropin-releasing hormone (TRH) promotes arousal and combats sleepiness associated with narcolepsy. Single-cell reverse-transcription-PCR demonstrated variable expression of the two known TRH receptors in the majority of...

Male Wistar rats maintained on a thiamine deficient diet showed mouse-killing aggression (muricide). On the 30th day of experimental feeding, the incidence of this muricide was about 70%. Intracerebroventricular histamine suppressed the muricide induced by thiamine deficiency in a dose-dependent manner. Histamine H1-receptor blocking agents such as diphenhydramine, promethazine and chlorphenira...

Aresh, B. 2016. Functional Aspects of Peripheral and Spinal Cord Neurons Involved in Itch and Pain. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1222. 48 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9568-8. We have investigated the role of the metabotropic glutamate receptor 7 (mGluR7) and the gastrin releasing peptide receptor (Grpr) pop...

The treatment options currently available for narcolepsy are often unsatisfactory due to suboptimal efficacy, troublesome side effects, development of drug tolerance, and inconvenience. Our understanding of the neurobiology of narcolepsy has greatly improved over the last decade. This knowledge has not yet translated into additional therapeutic options for patients, but progress is being made. ...