In spinal cord injuries, direct trauma by edges of sublaxated or dislocated vertebrae and indirect ischemia as a result of vascular injury necrotize the neural tissue. After spinal cord injury, tissue loss appears as micro- or macrocavitation. Accumulations of non-neuronal cells substitute spared tissue and halts axon regrowth. Lack of supporting cells (secreting trophic factors and matrix) agg...

About ten different European user groups work on biomedical research projects at the SRXRF/XANES-microprobe beamline L. For this community a dedicated one-day workshop about life science-applications at this beamline was held at HASYLAB on 17.03.2006. The workshop placed emphasis on different aspects of sample preparation techniques, but also general topics like imaging techniques in life scien...

Barrett's oesophagus is premalignant. Oesophagectomy is traditionally regarded as the standard treatment option in the presence of high grade intraepithelial neoplasia or intramucosal cancer. However, oesophagectomy is associated with high rates of mortality and morbidity. Endoscopic ablative therapies are limited by the lack of tissue for histological assessment, and the ablation may be incomp...

The histological diagnosis of any intra-thoracic mass by non-invasive techniques remains difficult. Those masses lying near the mediastinum may be accessible to bron-choscopy and biopsy whereas peripheral lesions adjacent to the rib cage are more suited to percutaneous needle biopsy. Computerised Tomography of the thorax provides vital information as to the physical structure and properties of ...

in pregnant mothers maternal diabetes happens when the pancreas cannot produce enough insulin, soblood glucose increases in the mother and then in the fetus, resulting in several injuries in neonates. thisstudy was conducted to evaluate the effects of maternal diabetes on fetal cerebrum. sixteen adult female rats were divided in two equal groups. diabetes was induced in one group by alloxan. bo...

As with so many studies requiring close clinicopathological correlation and specialised techniques, many of the major contributions to peripheral nevre pathology have been made by clinicians rather than pathologists. As a result, the general pathologist has tended to ignore many of the recent advances in peripheral nerve pathology and trainees in pathology often fail to appreciate that with rel...

Introduction: Environmental pollution with heavy metals such as mercury is a major health problem. Growing studies on the field have shown the deleterious effects of mercury on human and nonhuman nervous system, especially in infants, however the effects of prenatal exposure to mercuricchloride on cortical development are not yet well understood. The aim of this study was to investigate the eff...

In spinal cord injuries, direct trauma by edges of sublaxated or dislocated vertebrae and indirect ischemia as a result of vascular injury necrotize the neural tissue. After spinal cord injury, tissue loss appears as micro- or macrocavitation. Accumulations of non-neuronal cells substitute spared tissue and halts axon regrowth. Lack of supporting cells (secreting trophic factors and matrix) agg...

Nowadays, Histology is a science that is considered the "gold standard" to access anatomical information at a cellular level. In histology studies, tissue samples are cut into very thin sections, stained, and observed under the microscope by a specialist. Such studies, mainly about tissue structures, acellular components and their interactions, can be useful for the detection and diagnosis of c...

Specimens of marrow for histological examination may be obtained either by sectioning the particles present in a marrow aspirate or by surgical trephine of the sternum (Custer, 1933; Dameshek, Henstell, and Valentine, 1937; White, Baker, and Griffin, 1946). The former procedure is limited in many cases by the size of the particles withdrawn, while the latter, not infrequently, yields specimens ...