Previous studies have shown a generalised increase in bone mass in patients with osteoarthritis (OA). Using molecular histomorphometry, this study examined the in vivo expression of mRNA encoding bone anabolic factors and collagen type I genes (COL1A1, COL1A2) in human OA and non-OA bone. Bone samples were obtained from the intertrochanteric (IT) region of the proximal femur, a skeletal site di...

Background and Objective: It is conceivable that caffeine consumption would induce gonadal changes. The aim of this study is to assess the impact of embryonic caffeine exposure on rat testis and prostate. Materials and Methods: Female rats were divided into (n=7): A control, only received drinking water. B and C groups received caffeine low dose (26 mg/kg) and high dose (45 mg/kg) respectively...

Objective: The aim of this study was to assess, through biological analysis, the local effects and osseointegration dental implants incorporating surface micro/nanofeatures compared identical design without treatment. Background: Known impact bone cell behavior, chemical topography modifications target improved long-term success implants. Very few studies assess performance presenting both micr...

Abstract Background Bicuspid aortic valve (BAV) patients develop ascending (AAo) dilation. The pathogenesis of BAV-aortopathy (genetic vs. hemodynamic) remains unclear. Purpose To identify regional changes around the AAo wall in BAV with aortopathy integrating clinical imaging and molecular data. Methods (n=20) were recruited prospectively to surgically collect tissue perform four-dimensional c...

This study presents a histomorphometric and biomechanical comparison of bone response to commercially pure titanium screws with 4 different types of surface topographies placed in the tibial metaphysis of 12 rabbits. Each rabbit had 4 implants placed, 2 in each tibia. The 4 surface topographies were a machined surface, a grit-blasted surface, a plasma-sprayed surface, and an acid-etched (Osseot...

Histomorphometric analysis was performed on transiliac undecalcified bone biopsies taken from eight adults and four children with osteogenesis imperfecta. Double tetracycline labelling done before the biopsy allowed measurement of the calcification rate in 11 patients. The adults, as well as the children, had thin iliac cortices and considerably decreased trabecular bone volume. In addition, th...

BACKGROUND Several grafting materials have been used for alveolar ridge augmentation. The literature lacks researches to compare CenoBone to other grafting materials. The aim of this study was to compare CenoBone/CenoMembrane complex to Bio-Oss/Bio-Gide complex in lateral alveolar bone augmentation in terms of radiographic, histologic, and histomorphometric parameters. MATERIALS AND METHODS I...

PURPOSE To examine histological and histomorphometric techniques for measuring collagen in skeletal muscle. METHODS The following staining methods were used in the study: hematoxylin and eosin, Masson's trichrome, reticulin, and picrosirius red, and immunostaining for collagen types I, II, III, IV, and V. Histomorphometric measurements were performed using Corel PhotoPaint and UTHSCSA Image T...

OBJECTIVES To compare bioactive glass and autograft regarding their histomorphometric characteristics. METHODS The authors conducted a prospective case-control experimental study on animals in order to compare the histomorphometric characteristics of bioactive glass versus autograft. Eight rabbits underwent surgery in which a cavitary defect was created in both proximal femurs. One side was f...