Background Growing evidence indicates that AFAP1-AS1 plays an important role in various cancers, suggesting that it might be a potential cancer biomarker. Materials and Methods A meta-analysis was performed using microarray data obtained via the Affymetrix Human Genome U133 Plus 2.0 platform (found in the GEO database) and data obtained through a systematic search of PubMed and Web of Science...

To evaluate the clinical significance of lncRNAs in the resistance to cisplatin-based chemoradiotherapy in esophageal squamous cell carcinoma (ESCC). We focused on lncRNAs which were frequently reported in ESCC or were involved in chemoradiotherapy resistance. LncRNA expressions were examined in paired cisplatin-resistant and parental ESCC cell lines. Dysregulated lncRNAs were further measured ...

BACKGROUND Suitable diagnostic markers for cancers are urgently required in clinical practice. Long non-coding RNAs, which have been reported in many cancer types, are a potential new class of biomarkers for tumor diagnosis. RESULTS Five lncRNAs, including AK001058, INHBA-AS1, MIR4435-2HG, UCA1 and CEBPA-AS1 were validated to be increased in gastric cancer tissues. Furthermore, we found that ...

Despite the fact that most young patients with hyperglycemia are diagnosed type 1 (T1DM) and 2 (T2DM) diabetes, up to 10 % of all cases disease MODY diabetes. The common types GCK-MODY HNF1A-MODY, therefore investigation their clinical laboratory characteristics, including lipid spectrum indicators is high significance. aim this research work was study values in HNF1A-MODY at age from 18 45 yea...

Coronary artery disease is the leading cause of mortality and morbidity in the world. Left main coronary artery disease (LMCAD) is a particularly severe phenotypic form of CAD and has a genetic basis. We hypothesized that some inflammation- and hyperhomocysteinemia-related gene polymorphisms may contribute to LMCAD susceptibility in a Chinese population. We studied the association between polym...

Significant heterogeneity between different tumors prevents the discovery of cancer driver genes, especially in a patient-specific manner. We previously prioritized five personalized candidate mutation-driver genes in a hyper-mutated hepatocellular carcinoma patient using a multi-omics strategy. However, the roles of the prioritized driver genes and patient-specific mutations in hepatocarcinoge...

A total of 150 weanling pigs [(Landrace × Yorkshire) × Duroc, BW = 6.76 ± 0.61 kg] were used in a 42-d trial to investigate the effects of dietary Aviplus-S supplementation on growth performance, fecal score, fecal moisture, fecal pH, and blood profiles. Pigs were randomly assigned to 1 of 5 treatments according to BW. Dietary treatments were NC, basal diet (without antibiotics); PC, NC + 39 mg...

Data from the Pharmacogenomics and Risk of Cardiovascular Disease (PARC) study and the Cardiovascular Health Study (CHS) provide independent and confirmatory evidence for association between common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1a and plasma C-reactive protein (CRP) concentration. Analyses with the use of imputation-based methods to combine genotype data fro...