The original Hodgkin-Huxley model describes action potential generation in the squid giant axon and is a paradigm for conductance-based, excitable biological systems. Motivated by the recent theoretical work of Qiudong Wang and Lai-Sang Young, this paper examines the response of the Hodgkin-Huxley equations to low-frequency periodic pulsatile forcing. It is shown that 1. The pulse-driven Hodgki...

modern leukemia and lymphoma sequencing standards, is an improvement in signal-to-noise ratio for Hodgkin lymphoma given the incredible rarity of the Reed-Sternberg cell in its background nest of inflammatory infiltrate. Previous studies relying on laser capture microdissection could also increase the signal-to-noise ratio, but at the cost of time, effort, and still-low cell numbers. This work ...

Hipotermi ve hipotansiyon, etyolojisi bilinmeyen nadir bir fenomendir. Bu yazıda, hipertermi ile kendini gösteren, naproksen sodyum uygulaması sonrasında hipotermi gelişen evre IIIB Hodgkin hastalıklı bir olgu sunuldu. Bu olguda; naproksen uygulaması sonrası pirojenlerin üretiminin azalması, en muhtemel fizyopatolojik hipotez olarak gözükmektedir. Hipotermi daha kötü prognozla ilişkilendirilebi...

Treatment of patients with refractory Hodgkin lymphoma is a significant issue. We report a patient with Proteus syndrome and relapsed Hodgkin lymphoma, whose remission was finally achieved after brentuximab vedotin therapy, allowing her to receive a haploidentical stem cell transplant. The possible relationship between both disorders was discussed.

BACKGROUND Persons infected with human immunodeficiency virus (HIV) have an increased risk for several cancers, but the influences of behavioral risk factors, such as smoking and intravenous drug use, and highly active antiretroviral therapy (HAART) on cancer risk are not clear. METHODS Patient records were linked between the Swiss HIV Cohort Study and Swiss cantonal cancer registries. Observ...

PURPOSE Galectin-1 (Gal1) is an immunomodulatory glycan-binding protein regulated by an AP1-dependent enhancer in Hodgkin Reed-Sternberg cells. We recently found that Reed-Sternberg cell Gal1 promotes the immunosuppressive T-helper 2/T-regulatory cell-skewed microenvironment in classical Hodgkin lymphoma (cHL). We sought to investigate whether the coordinate expression of activated AP1 pathway ...

Tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 are proteins with proteinase-inhibiting and cytokine properties. TIMP-1 is active primarily in B cells and B-cell lymphomas, whereas TIMP-2 expression is restricted to T cells. The expression of TIMP-1 and TIMP-2 in lymph nodes from patients with Hodgkin disease (HD) and in Hodgkin-derived cell lines was investigated. In situ hybridizat...

The Hodgkin and Huxley equations model action potentials in squid giant axons. Variants of these equations are used in most models for electrical activity of excitable membranes. Computational tools based upon the theory of nonlinear dynamical systems are used here to illustrate how the dynamical behavior of the Hodgkin Huxley model changes as functions of two of the system parameters.

Primary pulmonary Hodgkin lymphoma (PPHL) is very rare and typically involves the superior portion of the lung. Pulmonary involvement is observed in 15-40% of Hodgkin lymphoma patients. Three such patients who presented with an unusual form of PPHL in radiological studies, i.e., multiloculated cavitary lesions, were admitted to our hospital. These lesions represent a new pathological and radiol...