Breast cancer is a heterogeneous disease that can be classified into several molecular intrinsic subtypes according to hormone markers, including estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2. Breast cancer cases with different hormone status vary with respect to patient morbidity, metastasis organotropism and disease progression. It is well known that th...

The androgen receptor (AR) is expressed in many cell types, and its related signaling widely investigated hormone-dependent cancers such as prostate breast. significance of the AR, however, has been detected even other cancers, including gastric, bladder, kidney, lung, hepatic, pancreatic, which growth spreading are not strictly or notoriously dependent on sex steroid hormone action. incidence ...

conclusions the inhibition of mini-puberty period in male rats was demonstrated to have an effect on their testicular function to some extent. results serum t and lh levels peaked at two hours after birth, while fsh peaked at hour 0, and bilateral testicular weight peaked at four hours after birth. the rats that underwent ether inhalation five minutes after birth had markedly reduced serum horm...

The article presents a clinical case illustrating the effectiveness of abemaciclib in combination with anastrozole metastatic estrogen receptor-positive HER2/neu-negative breast cancer (BC). CDK4/6 inhibitors have changed paradigm treatment patients hormone-positive HER2 BC. Thanks to ability palbociclib, ribociclib and delay overcome resistance endocrine therapy, not only newly diagnosed disea...

Sex hormones and their receptors play a crucial role in human sexual dimorphism have been traditionally associated with hormone-dependent cancers like breast, prostate, endometrial cancer. However, recent research has broadened our understanding by revealing connections other types of cancers, such as lung cancer, where the androgen receptor found to be particularly significant. This review aim...

Significance Lignin deposition in plants is affected by environmental stress, and stress-signaling involves increases the levels of plant hormone abscisic acid (ABA). Here we show, using a combination biochemical genetic approaches, how ABA can regulate lignin biosynthesis. This phosphorylation master transcription factor NST1 family protein kinases (SnRK2s) that are themselves activated as res...

primary growth hormone insensitivity syndrome (ghis) is a rare entity which can be due to defects in growth hormone (gh) receptor that is called type 1 laron syndrome (t1ls) or post receptor defects (type 2 laron syndrome ). the aim of study was determining the clinical and hormonal milieu of the patients with primary ghis and their response to igf-i (insulin like growth factor-i) generation te...