Sequence variation within enhancers plays a major role in both evolution and disease, yet its functional impact on transcription factor (TF) occupancy and enhancer activity remains poorly understood. Here, we assayed the binding of five essential TFs over multiple stages of embryogenesis in two distant Drosophila species (with 1.4 substitutions per neutral site), identifying thousands of orthol...

Purpose: This present study aimed to share experiences in the diagnosis and management of brain death (BD) cadaveric donation cases, detected a research hospital during COVID-19 pandemic.
 Materials Methods: BD cases diagnosed between 15/03/2020-15/05/2021 our intensive care units (ICU) were retrospectively evaluated. Patients’ demographic characteristics, primary diagnoses, ICU admission ...

Using a combination of active Radio-Frequency Identification tracking and staff interviews with members from an aerospace manufacturing company, it was uncovered that over 80 hours per week spent in the manual movement goods between departments. On site 1000 employees uses dedicated build cells separated departments, this mixed-use facility proves challenging for adoption autonomous delivery sy...

We document contemporaneous differences in the aggregate labor supply of married couples across 17 European countries and the US. Based on a model of joint household decision making, we quantify the contribution of international differences in non-linear labor income taxes and consumption taxes, as well as the educational composition, and gender wage gaps and educational premia, to the internat...

I propose a new measure of common, time-varying tail risk for large cross sections of stock returns. Stock return tails are described by a power law in which the power law exponent is allowed to transition smoothly through time as a function of recent data. It is motivated by asset pricing theory and is estimable via quasi-maximum likelihood. Estimates indicate substantial time variation in sto...

Using longitudinal data from Ukraine we examine the extent of any long-lasting effects of exposure to the Chernobyl disaster on the health and labour market performance of the adult workforce. Variation in the local area level of radiation fallout from the Chernobyl accident is considered as a random exogenous shock with which to try to establish its causal impact on poor health, labour force p...

Among the risk factors for hypertension, stress, especially work stress, has drawn increasing attention. Another potential work-related risk factor for hypertension identified in the past few years is work hours. This article presents an analysis of work hours and self-reported hypertension among the working population in the state of California. The data set used for this study comes from the ...

We clarify the empirical source of the debate on the effect of technology shocks on hours worked. We argue that the contrasting conclusions from level and difference VAR specifications are not primarily due to the presence or absence of a unit root in hours worked. Rather they are due to a small, but important, low frequency comovement between hours worked and labour productivity growth. This c...

We ask two questions related to how access to credit affects the nature of business cycles. First, does the standard theory of unsecured credit account for the high volatility and procyclicality of credit and the high volatility and countercyclicality of bankruptcy filings found in U.S. data? Yes, it does, but only if we explicitly model recessions as displaying countercyclical earnings risk (i...