Bay leaf (Syzygium polyanthum (Wight.) contains polyphenolic compounds that are beneficial in the treatment of hypercholesterolemia by reducing Low Density Lipoprotein (LDL) levels. The dosage form mucoadhesive microgranules is able to prolong active substance contact time with mucosa give better therapeutic effect. This study aims make bay extract different polymers Hydroxy Propyl Methyl Cellu...

Buccoadhesive tablets of Metclopramide Hydrochloride were fabricated with objective of avoiding extensive first pass metabolism and to prolong its duration of action with reduction in dosing frequency. The mucoadhesive polymers used in the formulations were Carbopol 934P, Chitosan, HPMC K4M and HPMC K15M. Tablets were prepared by direct compression method using polymer in different ratios. The ...

Psyllium has a mucilaginous property that makes it a good candidate to be utilized as an excipient in the preparation of controlled release systems. Various formulations were prepared using theophylline as a model drug and investigated with a view to achieve an ideal slow drug release profile. The addition of hydroxypropyl methylcellulose (HPMC) to psyllium significantly reduced the burst relea...

Enteric coated oral tablets or capsules can deliver dried live cells directly into the intestine. Previously, we found that a live attenuated bacterial vaccine acquired sensitivity to intestinal bile when dried, raising the possibility that although gastric acid can be bypassed, significant loss of viability might occur on release from an enteric coated oral formulations. Here we demonstrate th...

The aim of the current study was to design an oral sustained release matrix tablet of metformin HCl and to optimize the drug release profile using response surface methodology. Tablets were prepared by non-aqueous wet granulation method using HPMC K 15M as matrix forming polymer. A central composite design for 2 factors at 3 levels each was employed to systematically optimize drug release profi...

The aim of this study was to develop an alternative method for enteric coating of HPMC capsules that avoids the sealing step before coating, resulting in ready-to-use enteric-coated capsules for the use in retail or hospital pharmacy or R&D sections of pharmaceutical industry and for the production of enteric-coated heat and moisture sensitive biomaterials. HPMC caps and bodies 00 (Vcaps, Capsu...

Guaifenesin, a highly water-soluble active (50 mg/mL), classified as a BCS class I drug. Owing to its poor flowability and compressibility, formulating tablets especially high-dose one, may be a challenge. Direct compression may not be feasible. Bilayer tablet technology applied to Mucinex®, endures challenges to deliver a robust formulation. To overcome challenges involved in bilayer-tablet ma...

The main aim of this study was preparation and evaluation of extended - release system ofthe anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general propertiessimilar to those of diazepam. Our studies focused on development of extended drug deliverysystem based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent andPolyvinylpyrrolidone (PVP k30) as binder us...

Abstract The present study introduces an overview of gentamicin-clay mineral systems for applications in biomedicine and then focuses on the development a series gentamicin/clay hybrid materials to be used as bioactive phase hydroxypropylmethylcellulose (HPMC) produce bionanocomposite membranes possessing antimicrobial activity interest wound-dressing applications. Gentamicin (Gt) was adsorbed ...