OBJECTIVE Factors influencing long-term viability of an intermediated regional food supply network (food hub) were modeled using agent-based modeling techniques informed by interview data gathered from food hub participants. BACKGROUND Previous analyses of food hub dynamics focused primarily on financial drivers rather than social factors and have not used mathematical models. METHOD Based ...

in this paper, a hierarchical p-hub median problem is considered that all the nodes and arcs on the network have limited capacities. proposed model has three-level where the complete network at the top level consists of the central hubs. the second and third levels consist of hub and demand nodes respectively, which are connected through star networks. also, delivery time restriction is taken i...

The third Heidelberg Unseminars in Bioinformatics (HUB) was held on 18th October 2012, at Heidelberg University, Germany. HUB brought together around 40 bioinformaticians from academia and industry to discuss the 'Biggest Challenges in Bioinformatics' in a 'World Café' style event.

We investigate the economic hubs and authorities of the world trade network (WTN) from 1992 to 2012, an era of rapid economic globalization. Using a well-defined weighted hyperlink-induced topic search (HITS) algorithm, we can calculate the values of the weighted HITS hub and authority for each country in a conjugate way. In the context of the WTN, authority values are large for countries with ...

The objective of this study was to identify hub genes and pathways associated with hepatocellular carcinoma (HCC) by centrality analysis of a co-expression network. A co-expression network based on differentially expressed (DE) genes of HCC was constructed using the Differentially Co-expressed Genes and Links (DCGL) package. Centrality analyses, for centrality of degree, clustering coefficient,...

Abstract. Given the demand between each origin-destination pair on a network, the planar hub location problem is to locate the multiple hubs anywhere on the plane and to assign the traffic to them so as to minimize the total travelling cost. The trips between any two points can be nonstop (no hubs used) or started by visiting any of the hubs. The travel cost between hubs is discounted with a fa...

To resolve the difficulties in deployment of the classic security solution S-BGP (Secure Border Gateway Protocol), the Translator Trust Model (TTM) for a new solution SE-BGP (Security Enhanced BGP) was proposed to transform the centralized deployment mode of S-BGP to distributed mode. However, the trust (attestations of routing information) translation of TTM only depends on a single hub node a...

In the next few years, Brazil will host international events such as the 2014 FIFA World Cup and the 2016 Olympics Games. Given the worldwide appeal of these events, local authorities in Brazil expect the country will have around 1.6 million visitors arriving at its airports (1 million for the Olympics and 600 thousand for the World Cup). Therefore, these events will put to test the robustness ...

The niche directs key behaviors of its resident stem cells, and is thus crucial for tissue maintenance, repair and longevity. However, little is known about the genetic pathways that guide niche specification and development. The male germline stem cell niche in Drosophila houses two stem cell populations and is specified within the embryonic gonad, thus making it an excellent model for studyin...

Microarray data were collected from bile duct samples from subjects with malignant biliary strictures by endoscopic retrograde cholangiopancreatography to screen for key genes associated with this disease. A predicted interaction network was constructed for these genes to interpret their functions. The gene expression dataset GSE34166 (10 samples: 6 malignant and 4 benign control samples) was d...