This study was aimed to evaluate the influence of Human Leukocyte Antigens- G (HLA-G) gene polymorphisms on risk rheumatoid arthritis (RA). In present study, blood samples were collected from 100 patients and healthy controls. Serum levels HLA-G in both controls measured using ELISA kit which shown a higher significant differences (p< 0.05) comparison between them (539.3 ng/ml 139.3ng/ml) re...

OBJECTIVE To determine the association between mediastinal fibrosis and human leukocyte antigen (HLA) genes. DESIGN Case-control study. SETTING Vanderbilt University Medical Center. SUBJECTS Nineteen consecutive patients with mediastinal fibrosis who presented to the pulmonary clinic at Vanderbilt University Medical Center from 1987 to 1996. The control subjects were 21,086 whites who wer...

Human leukocyte antigen G (HLA-G) is a non-classic class I major histocompatibility complex (MHC) molecule characterized by low polymorphism in its coding region, a limited tissue distribution pattern in physiologic conditions, and expression through soluble isoforms and isoforms bound to surface membranes through alternative splicing. HLA-G is fairly known since it is involved in induction and...

Human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule with known immune-modulatory functions. Our group identified a subset of human dendritic cells, named DC-10, that induce adaptive interleukin-10-producing T regulatory type 1 (Tr1) cells via the interleukin-10-dependent HLA-G/ILT4 pathway. In this study we aimed at defining the role of HLA-G in DC-10-mediated Tr1 cell diffe...

background: the human leukocyte antigen-drb1 (hla-drb1) locus is one of the most polymorphic human loci and has a crucial role in the immune system. assessing the allelic frequencies of hla-drb1 locus would be a fundamental factor in defining the origin of populations, relationships with other populations, disease association studies and the constitution of unrelated bone marrow donor registrie...

Objective To better characterize the genetic association between human leukocyte antigen (HLA) and anti-IgLON5 disease to explore auto-antigen binding associated HLA molecules their functional involvement in pathophysiology. Background Anti-IgLON5 is a rare, but likely underdiagnosed type of autoantibody encephalitis with heterogeneous clinical phenotype, including sleep, movement brainstem dys...

Abstract The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has turned into a pandemic with about thirty million confirmed cases worldwide as of September 2020. Being an airborne infection, it can be catastrophic to populous countries like India. This study sets identify potential cytotoxic T lymphocyte (CTL) epitopes in the SARS-CoV-2 Indian isolate which act effective vaccine ep...