Epithelial ovarian cancer (EOC) is the most common gynecologic malignancy. To identify the micro-ribonucleic acids (miRNAs) expression profile in EOC tissues that may serve as a novel diagnostic biomarker for EOC detection, the expression of 1722 miRNAs from 15 normal ovarian tissue samples and 48 ovarian cancer samples was profiled by using a quantitative real-time polymerase chain reaction (q...

OBJECTIVE Currently, there is not a fully characterized model for human ovarian cancer; however, 2- to 4-year-old laying hens spontaneously develop ovarian tumors. CA125 expression is a hallmark of ovarian cancer in women. The major objective of this study was to characterize the in vitro growth of avian ovarian tumor cells, and CA125 expression in avian ovarian tumors. METHODS Immunohistoche...

Advances in the diagnosis and treatment of cancer have resulted in a growing population of adolescent and adult long-term survivors of malignancies with infertility problems due to induced premature ovarian failure. Although several options are currently available to preserve fertility in cancer patients, cryopreservation of ovarian tissue is the only option available for prepubertal girls and ...

The existence of the enzyme prostaglandin E-2-9-ketoreductase which can convert prostaglandin E-2 to prostaglandin F-2 alpha was indicated in experiments with pig and human ovarian tissues in vitro, using radioimmunoassay methods and a superfusion technique. Further studies involving radiotracer techniques demonstrated that the enzyme was localized in the high-speed (105 000 g) supernatant frac...

BACKGROUND The stripping technique for endometriomas excision has been reported to be associated with follicular loss. The objective of this trial was to evaluate the presence and nature of ovarian tissue adjacent to the endometrioma cyst wall obtained by stripping with different techniques. METHODS Forty-eight patients with ovarian endometrioma were enrolled in two consecutive independent ra...

To clarify the pathogenesis of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in patients without ovarian teratoma, we investigate normal human ovary, normal bovine ovary and bovine ova. On the basis of immunohistochemical studies, normal human ovary expressed NR2B epitope in primordial oocytes. The results of SDS-PAGE and immunoblotting using bovine ovarian tissues and ova, we identif...

conclusions hpv type 16 was detected in only 9.67% of malignant epithelial tumors. it appears that hpv infection plays a relatively minor role in the pathogenesis of ovarian carcinomas. results out of the eight cases with functional cysts only one case (12.5%) expressed hpv. no hpv expression was seen in cases with benign and borderline tumors. out of the 31 cases with one malignant surface epi...

PURPOSE Most patients with ovarian carcinomas succumb to their disease and there is a critical need for improved therapeutic approaches. Carcinomas arising in BRCA mutation carriers display defective DNA double-strand break repair that can be therapeutically exploited by inhibition of PARP-1, a key enzyme in the repair of DNA single-strand breaks, creating synthetic lethality in tumor cells. ...

It has been previously shown (J. Schneider et al., Br. J. Cancer, 77: 1015-1020, 1998) that an antibody directed against Candida albicans proteins (C6) recognizes specifically a protein in human ovarian tumors. We have now performed an immunoscreening of a human cDNA library using this antibody and identified the antigen as Nup88, a protein localized preferentially at the nuclear membrane and p...

Ovarian Remnant syndrome (ORS) is the presence of residual ovarian tissue after an oophorectomy was performed whether associated with a hysterectomy or not. We report case 39-year-old woman past surgical history total abdominal and left salpingo-oophorectomy indication placenta accreta incidentally discovered during caesarian section. The patient presented pelvic pain diagnosed ORS. She success...