A combination of functional studies on human papillomavirus (HPV) oncoproteins and epidemiological studies on persistence of HPV infection firmly established a role for HPV in the etiology of cervical cancers. Understanding the viral life cycle of HPVs has been more difficult. In this issue of Genes & Development, Wang et al. (pp. 181 - 194) describe an efficient method to propagate infectious ...

Information is provided for clinicians who treat adolescents and adult women to use when counseling patients about human papillomavirus (HPV) vaccine. A literature search was done to determine: (1) reasons for refusal of the vaccine, including cost and concerns that immunization against HPV will lead to promiscuity; (2) potential for non-sexual transmission of HPV; (3) non-genital locations of ...

INTRODUCTION The aim of this study was to examine the knowledge of Belgian university students about the human papillomavirus (HPV) and HPV-vaccination. MATERIAL AND METHODS During a period of two months we administered an online questionnaire, which contained 29 questions, to 3332 students of the Free University of Brussels. Of the 433 completed questionnaires, 346 were included by age (18-3...

Human papillomavirus type 16 (HPV-16) is strongly implicated in the aetiology of premalignant and malignant disease of the cervix. The mechanisms by which HPV-16 induces cell transformation have been the subject of intense investigation for several years. The viral genome encodes three oncoproteins, E5, E6 and E7, but until recently only E6 and E7 were subjected to such scrutiny. The papillomav...

A human papillomavirus (HPV) infection is globally one of the most common causes sexually transmitted infections mucous membranes (genital, anal and oral). Over last decade, an increasing number young patients have been infected due to changes in sexual habits general population. The majority lesions are benign; however, substantial scientific evidence has suggested a role for HPV family carcin...

The greatest risk factor for the development of cervical and other cancers that have been linked to the human papillomavirus (HPV) family is the persistence of the virus. To persist for the decades required to develop HPV-related cancers, the virus must escape host immunity. HPV is a simple DNA virus that has evolved to escape immune attack by a combination of stealth and interference. This rev...

  Background and Objectives: Some of the human papillomaviruses (HPVs) can infect genital tracts and are sometimes associated with anogenital tract cancers. HPVs induced cervical cancers through the expression of E6 and E7 genes by inactivating the tumor suppressor proteins. In this study, E6 and E7 genes were chosen in order to construct an expression vector which is able to express ...

OBJECTIVE Human papillomavirus (HPV) is a necessary cause for cervical cancer, and it has been associated with vulvar and vaginal cancer and vulvar (VIN) and vaginal (VaIN) and anal (AIN) intraepithelial neoplasia. We assessed the prevalence of HPV (and the types) to estimate the possible effect of a HPV vaccine on lower genital tract disease prevention. METHODS Two hundred fifty-eight sample...

(Abstracted from N Engl J Med 2021;385:1908–1918) In May 2018, the World Health Organization (WHO) called for elimination of global cervical cancer as a major public health priority, with 2-pronged approach focusing on effective vaccination against human papillomavirus (HPV) and screening treatment early cancer. Cervical is considered largely preventable through these programs; however, it cont...

In 2006, an adjuvant vaccine against 4 human papillomavirus (HPV) types was licensed. By 2012, 45 countries had introduced HPV vaccination. HPV encompasses a group of more than 100 viruses, of which at least 13 are high-risk types, responsible for cervical and other anogenital cancers. There are currently 2 vaccines that prevent HPV 16 and 18 infection (known to cause 70% of cervical cancers) a...