Female germline stem cells (FGSCs) or oogonial stem cells (OSCs) have the capacity to generate newborn oocytes and thus open a new door to fight ovarian aging and female infertility. However, the production and identification of OSCs are difficult for investigators. Rare amount of these cells in the ovary results in the failure of the acquisition of OSCs. Furthermore, the oocyte formation by OS...

Cell Therapy For Therapeutic Vascularization Endothelial Progenitor Cells and Postnatal Vasculogenesis: Experimental Evidence The option of performing full-scale endothelial cell transplantation to optimize local neovascularization is daunting if even feasible. An alternative, attractive strategy is designed to exploit the conceptual notion that endothelial cells and hematopoietic stem cells we...

BACKGROUND Wound healing is a complex and dynamic process following damage in tissue structures. Due to extensive skin damage caused by burn injuries, this study determined the role of human adult peripheral and umbilical cord blood platelet-rich plasma on proliferation and migration in human skin fibroblasts. METHODS Platelet-rich plasma (5, 10, 15, 20 and 50% PRP) from human umbilical cord ...

Status epilepticus (SE) is a condition of persistent seizure that leads to brain damage and, frequently, to the establishment of chronic epilepsy. Cord blood is an important source of adult stem cells for the treatment of neurological disorders. The present study aimed to evaluate the effects of human umbilical cord blood mononuclear cells (HUCBC) transplanted into rats after induction of SE by...

background , despite numerous studies over a decade, it still remains controversial about the biological effects of rf emf emitted by mobile phone telephony. objective , here we investigated the effect of 900 mhz gsm on the induction of oxidative stress and the level of intracellular reactive oxygen species (ros) in human mononuclear cells, monocytes and lymphocytes as defence system cells. met...

Cellular therapy for spinal cord injury (SCI) is overviewed focusing on bone marrow mononuclear cells, olfactory ensheathing cells, and mesenchymal stem cells. A case is made for the possibility of combining cell types, as well as for allogeneic use. We report the case of 29 year old male who suffered a crush fracture of the L1 vertebral body, lacking lower sensorimotor function, being a score ...

hematopoietic cord blood (cb) stem cell transplantation has more advantages to other cell sources because of lower graft versus host disease (gvhd). interleukin-15(il-15) is an immunoregulatory cytokine, known to enhance cytolytic function of cord natural killer (nk) cells. the aim of this study was to investigate the effect of il-15 on nk cytotoxicity simultaneously in different cell death sta...

Rodent mast cells (MCs) are reported to play a pivotal role in both innate and adaptive immunity. However, there is so far no evidence that human MCs are involved in innate immunity. We found that a functional Toll-like receptor 4 (TLR4) was expressed on human MCs when it was up-regulated by interferon (IFN). To systematically explore how human MCs modulate the immune system following TLR4-medi...

Mesenchymal stem cells (MSCs) are multi-potent progenitor cells with ability to differentiate into multiple lineages, including bone, cartilage, fat, and muscles. Recent research indicates that MSCs can be efficiently recruited to tumor sites, modulating tumor growth and metastasis. However, the underlying molecular mechanisms are not fully understood. Here, we first demonstrated that human umb...

Background aimsStem cell transplantation is a potential treatment for intractable spinal cord injury (SCI), and allogeneic human umbilical mesenchymal stem cells (hUC-MSCs) are promising candidate because of the advantages immune privilege, paracrine effect, immunomodulatory function, convenient collection procedure little ethical concern, there an urgent need to develop safe effective protocol...