PURPOSE In the treatment of interstitial cystitis, intravesical hyaluronic acid application may be suggested as a treatment option. In this randomized prospective study, the authors aimed to identify whether instilling the hyaluronic acid with electromotive drug administration (EMDA) would increase the tissue uptake and improve the efficacy. MATERIALS AND METHODS The data of 31 patients who h...

ABS TRACT Introduction: Cutaneous fillings are a common procedure in today’s dermatology, with the majority being carried out with hyaluronic acid isolated or combined with other substances. Objective: To study the effects of adding hyaluronic acid and polyethylene glycol to cultures of human dermal fibroblasts. Methods: The study evaluated: cell proliferation and production of type 1 collagen ...

UNLABELLED The vibration of the vocal fold lamina propria is an important factor involved in vocal production and aging may change the amount of hyaluronic acid in the vocal fold leading to dysphonia. AIMS This study compares the concentration of hyaluronic acid in vocal folds of aged and young female rats. STUDY DESIGN experimental. MATERIALS AND METHODS We used the vocal cords of 13 fem...

It has been demonstrated in vitro that low concentrations of ascorbic acid rapidly depolymerize purified hyaluronic acid as judged from viscosity measurements (Skanse and Sundblad, 1943; Pigman, Rizvi, and Holley, 1961). Abrams and Sandson (1964) reported that the hyaluronic acid in rheumatoid synovial fluid is resistant to depolymerization by ascorbic acid in vitro. Serum proteins have been sh...

This work follows from that of Blumberg & Ogston (1957). They showed that papain is a specific agent for degrading the protein part of the hyaluronic acid complex isolated from ox synovial fluid by filtration (Ogston & Stanier, 1950), and that when this protein is degraded marked changes in the non-Newtonian viscosity occur. This is associated with a marked decrease in the molecular weight and ...

A method for making mucopolysaccharide molecules visible in the electron microscope is reported and is applied to elucidate the structure of hyaluronic acid. The method is essentially that of Kleinschmidt and Zahn' 2 for nucleic acids: the polyanion strands are combined with a positively charged protein, such as cytochrome c, incorporated into a surface film of the protein, and then shadowed wi...

AN attempt has been made to find the cells of origin and the time of origin during development of the vitreous hyaluronic acid. The adult vitreous body of those species so far examined seems to owe its characteristic jelly-like properties to the presence of small amounts of an insoluble collagen-like protein laid down in fibrous lamellae and a low concentration of hyaluronic acid. Earlier work ...

UNLABELLED Hormone plays an important role in the larynx. Among other substances, vocal folds contain hyaluronic acid, which tissue concentration may vary according to hormone action. AIM the objective of this study is to analyze hyaluronic acid concentration in the vocal folds during estral and gravidic-puerperal cycles. MATERIALS AND METHODS Experimental study. 40 adult rats were divided ...

BACKGROUND A double-network (DN) gel, which was composed of poly-(2-Acrylamido-2-methylpropanesulfonic acid) and poly-(N,N'-dimethyl acrylamide) (PAMPS/PDMAAm), has the potential to induce chondrogenesis both in vitro and in vivo. The present study investigated whether DN gel induced chondrogenic differentiation of ATDC5 cells in a maintenance medium without insulin, and whether supplementation...

The cell-free synthesis of hyaluronic acid has been demonstrated in extracts of cultured human fibroblasts. Preparations from fibroblasts of normal individuals as well as those from patients with Marfan syndrome incorporate glucuronic acid and N-acetylglucosamine from their UDP derivatives into hyaluronic acid. Extracts from Marfan fibroblasts demonstrate 3 to 10 times more total and specific h...