The SecY protein is a membrane-bound factor required for bacterial protein export and embedded in the cytoplasmic membrane by its 10 transmembrane segments. We previously proposed a topology model for this protein by adapting the Manoil-Beckwith TnphoA approach, a genetic method to assign local disposition of a membrane protein from the enzymatic activity of the alkaline phosphatase (PhoA) matu...

The aim of this work is to illustrate the structural and parametric optimization of continuous hybrid distillation-pervaporation process with different configurations such as series, parallel, and series-parallel arrangement of pervaporation modules in the pervaporation network, and to propose a generalized methodology for difficult separations. A superstructure representation of hybrid process...

Nonaqueous redox flow batteries (NARFBs) hold potential application as an electricity energy storage for intermittent renewable and can operate with high voltage density. However, their further development is impeded by lack of a proper membrane. Herein, flexible freestanding anionic metal–organic framework (MOF)-based membrane prepared through solution casting method, MOF (UiO-66-SO3Li) polyvi...

Antimicrobial peptides have attracted considerable attention because of their broad-spectrum antimicrobial activity and their low prognostic to induce antibiotic resistance which is the most common source of failure in bacterial infection treatment along with biofilms. The method to design hybrid peptide integrating different functional domains of peptides has many advantages. In this study, we...

OBJECTIVE Propagation of depolarisation and repolarisation in myocardium results from an interplay of membrane potential, transmembrane current, and intercellular current. This process can be represented mathematically with a reaction-diffusion (RD) equation. Solving RD equations for a whole heart requires a supercomputer. Therefore, earlier models used predefined action potential (AP) shapes a...

the polysulfone-based membrane has been used in hemodialysis (hd) and it is continuously developed to maintain its sustainability on the subject of biocompatibility. during the polysulfone-based membrane development, several parameters should be considered to improve the membrane performances, such as excellent biocompatibility, appropriate ultrafiltration rate, and effective clearance of the t...

The yeast two-hybrid system represents one of the most efficient approaches currently available for identifying and characterizing protein-protein interactions [1-4]. Although very powerful, this procedure exhibits several problems and inherent limitations [5]. A new system, the Sos recruitment system (SRS), was developed recently [6] based on a different readout from that of the two-hybrid sys...

It is still very challenging to achieve effective combination of carbon nanofibers and graphene sheets. In this study, a novel and facile method is developed to prepare flexible graphene/carbon nanofiber (GCNF) membranes with every carbon nanofiber wrapped by conductive graphene sheets, resulting in a remarkable improvement of their electrical conductivity. This method only entails a moderate p...

This paper presents a hybrid approach based on appropriately combining Differential Evolution algorithms and Tissue P Systems (DETPS for short), used for solving a class of constrained manufacturing parameter optimization problems. DETPS uses a network membrane structure, evolution and communication rules like in a tissue P system to specify five widely used DE variants respectively put inside ...

Meng JJ, Bornslaeger EA, Green KJ et al. (1997) Two-hybrid analysis reveals fundamental differences in direct interactions between desmoplakin and cell type-specific intermediate filaments. J Biol Chem 272: 21495–503 Pasdar M, Krzeminski KA, Nelson WJ (1991) Regulation of desmosome assembly in MDCK epithelial cells: coordination of membrane core and cytoplasmic plaque domain assembly at the pla...