We examine how different transcriptional network structures can evolve from an ancestral network. By characterizing how the ancestral mode of gene regulation for genes specific to a-type cells in yeast species evolved from an activating paradigm to a repressing one, we show that regulatory protein modularity, conversion of one cis-regulatory sequence to another, distribution of binding energy a...

Hybrid waveguides consisting of a metal plane separated from a high-index medium by a low-index spacer have recently attracted a lot of interest. TM and TE modes are guided in two different layers in these structures and their properties can be controlled in different manners by changing the waveguide dimensions and material properties. We examine the effects of different parameters on the char...

tomato as a highly nutritious vegetable crop is widely grown in the world. hybrid seed is preferably used for tomato production. identification of superior hybrid combination is one of the most important steps in the hybrid breeding programs. breeding of high yielding hybrids is expensive and involves testing large numbers of hybrid combinations in multi-environment trials. successful predictio...

This paper conducts a two-period dynamic analysis of sourcing mode choices for e-commerce projects implemented by large firms during 1999–2002. We 48 KISHORE, AGRAWAL, AND RAO differentiate e-commerce assets that are the focus of a sourcing decision in terms of whether they are in the growth or maturity stages. We also consider hybrid governance mechanisms, such as minority equity arrangements,...

An investigation of the chromatic properties of waveguide lenses is described. In general, the focal length of mode-index and Fresnel zone (diffractive) lenses will be a function of wavelength. As a result, these lenses will have high optical quality over only a relatively small wavelength range. A method is given to correct for this chromatic dispersion by forming a hybrid mode-index/diffracti...

Hybrid systems whose mode dynamics are governed by nonlinear ordinary differential equations (ODEs) are often a natural model for biological processes. However such models are difficult to analyze. To address this, we develop a probabilistic analysis method by approximating the mode transitions as stochastic events. We assume that the probability of making a mode transition is proportional to t...

Transport mode information is essential for understanding people’s movement behavior and travel demand estimation. Current approaches extract travel information once the travel is complete. Such approaches are limited in terms of generating just-in-time information for a number of mobility based applications, e.g., real time mode specific patronage estimation. In order to detect the transport m...

This paper presents a hybrid electric scooter model developed and simulated using Matlab/Simulink. This hybrid scooter modeled has a parallel hybrid structure. The main propulsion units consist of a two stroke internal combustion engine and a hub motor attached to the front wheel of the scooter. The methodology used to optimize the energy and fuel consumption of the hybrid electric scooter is t...

We develop an integrated/hybrid optimization model for configuring new products’ supply chains while explicitly considering the impact of demand dynamics during new products’ diffusion. The hybrid model simultaneously determines optimal production/sales plan and supply chain configuration. The production and sales plan provides decisions on the optimal timing to launch a new product, as well as...

design of bridge deck with long-term strength, durability and permanence is a significant interest for engineers. one applicable solution to this challenge could be via using hybrid system consisting of conventional materials such as concrete and steel with frp plates which is also known as composite deck. since these deck are relatively new so their performance is not completely known. the pre...