A novel approach of the convergent functionalisation of aryl dibromides to form NS5A type inhibitors using C-H activation is reported. The focus of investigation was to reduce the formation of homodimeric side product, as well as to investigate the scope of different aryl dibromides that were tolerated under the reaction conditions. The C-H activation methodology was found to give a viable synt...

Over recent decades, electromagnetic methods have been viewed with considerable suspicion by many in the hydrocarbon exploration industry. While highly effective in mineral and environmental geophysics, electro m a g n e t i c methods have played a minor role in hydrocarbon exploration. Since electromagnetic (EM) methods use signals that diffuse in the Earth, they cannot provide the same vertic...

The 2H NMR transverse relaxation rates of a deuterated phospholipid bilayer reflect slow motions in the bilayer membrane. A study of dimyristoyl lecithin specifically deuterated at several positions of the hydrocarbon chains indicates that these motions are cooperative and are confined to the hydrocarbon chains of the lipid bilayer. However, lipid head group interactions do play an important ro...

Antimicrobial peptides are promising candidates for anti-infective pharmaceuticals. Unfortunately, because of their low proteolytic and chemical stability, their usage is generally narrowed down to topical formulations. Until now, numerous approaches to increase peptide stability have been proposed. One of them, peptide hydrocarbon stapling, a modification based on stabilizing peptide secondary...

List of Abbreviations CIIAPTER ONE General Introduction Pollution of Saudi Arabian soil with crude oil Chemistry and biodegradability of petroleum hydrocarbon Environmental fate of petroleum Factors influencing petroleum hydrocarbon biodegradation Distribution of petroleum-utilizing microorganisms in the environment Biological degradation of petroleum hydrocarbon Bacterial degradation of oil Fu...

With its important geostrategic location, valuable marine resources and rich hydrocarbon deposits, the South China Sea has become epicenter of many ongoing territorial maritime conflicts. The European Union (EU) also vital interests potential key roles in this region. In article, conflicttransforming that EU can play conflict are analyzed within framework conditionality policy, social learning ...

thermal cracking of a heavy liquid hydrocarbon was performed in a laboratory scale tubular reactor. central composite design (ccd), was used as an experimental design method. the design variables were coil outlet temperature (cot), feed flow and rate steam ratio. maximum yield of ethylene was 30.37 wt% at cot, residence time and steam ratio of 869oc, 0.208 s and 1.22 g/g, respectively. maximum ...

petroleum hydrocarbons are important energy resources used by industry and in our daily life, whose production contributes highly to environmental pollution. to control such risk, bioremediation constitutes an environmentally friendly alternative technology that has been established and applied. it constitutes the primary mechanism for the elimination of hydrocarbons from contaminated sites by ...

The palladium-catalysed reaction of alkynyltriarylborates with aryl halides afforded trisubstituted alkenylboranes, in which two different aryl groups were installed across the carbon-carbon double bond in a cis arrangement.

An efficient site selective method for the direct arylation of free-(NH2) adenines 1 to provide a range of C-8 arylated adenines 3 in excellent yields is described. This process based on the use of Pd(OH)2/C as the catalyst and a stoichiometric amount of CuI under ligandless conditions is general. It allows the coupling to proceed with a variety of aryl halides, including for the first time che...